Abscission checkpoint control: stuck in the middle with Aurora B

At the end of cell division, the cytoplasmic bridge joining the daughter cells is severed through a process that involves scission of the plasma membrane. The presence of chromatin bridges ‘stuck’ in the division plane is sensed by the chromosomal passenger complex (CPC) component Aurora B kinase, t...

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Detalles Bibliográficos
Autor principal: Carmena, Mar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2012
Materias:
Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411112/
https://www.ncbi.nlm.nih.gov/pubmed/22870391
http://dx.doi.org/10.1098/rsob.120095
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author Carmena, Mar
author_facet Carmena, Mar
author_sort Carmena, Mar
collection PubMed
description At the end of cell division, the cytoplasmic bridge joining the daughter cells is severed through a process that involves scission of the plasma membrane. The presence of chromatin bridges ‘stuck’ in the division plane is sensed by the chromosomal passenger complex (CPC) component Aurora B kinase, triggering a checkpoint that delays abscission until the chromatin bridges have been resolved. Recent work has started to shed some light on the molecular mechanism by which the CPC controls the timing of abscission.
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spelling pubmed-34111122012-08-06 Abscission checkpoint control: stuck in the middle with Aurora B Carmena, Mar Open Biol Commentaries At the end of cell division, the cytoplasmic bridge joining the daughter cells is severed through a process that involves scission of the plasma membrane. The presence of chromatin bridges ‘stuck’ in the division plane is sensed by the chromosomal passenger complex (CPC) component Aurora B kinase, triggering a checkpoint that delays abscission until the chromatin bridges have been resolved. Recent work has started to shed some light on the molecular mechanism by which the CPC controls the timing of abscission. The Royal Society 2012-07 /pmc/articles/PMC3411112/ /pubmed/22870391 http://dx.doi.org/10.1098/rsob.120095 Text en http://creativecommons.org/licenses/by/3.0/ © 2012 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/, which permits unrestricted use, provided the original author and source are credited.
spellingShingle Commentaries
Carmena, Mar
Abscission checkpoint control: stuck in the middle with Aurora B
title Abscission checkpoint control: stuck in the middle with Aurora B
title_full Abscission checkpoint control: stuck in the middle with Aurora B
title_fullStr Abscission checkpoint control: stuck in the middle with Aurora B
title_full_unstemmed Abscission checkpoint control: stuck in the middle with Aurora B
title_short Abscission checkpoint control: stuck in the middle with Aurora B
title_sort abscission checkpoint control: stuck in the middle with aurora b
topic Commentaries
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411112/
https://www.ncbi.nlm.nih.gov/pubmed/22870391
http://dx.doi.org/10.1098/rsob.120095
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