Resampling QTL Effects in the QTL Sign Test Leads to Incongruous Sensitivity to Variance in Effect Size

Allelic effects at quantitative trait loci (QTL) between lineages are potentially informative for indicating the action of natural selection. The QTL Sign Test uses the number of + and − alleles observed in a QTL study to infer a history of selection. This test has been constructed to condition on t...

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Autores principales: Rice, Daniel P., Townsend, Jeffrey P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2012
Materias:
Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411246/
https://www.ncbi.nlm.nih.gov/pubmed/22908039
http://dx.doi.org/10.1534/g3.112.003228
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author Rice, Daniel P.
Townsend, Jeffrey P.
author_facet Rice, Daniel P.
Townsend, Jeffrey P.
author_sort Rice, Daniel P.
collection PubMed
description Allelic effects at quantitative trait loci (QTL) between lineages are potentially informative for indicating the action of natural selection. The QTL Sign Test uses the number of + and − alleles observed in a QTL study to infer a history of selection. This test has been constructed to condition on the phenotypic difference between the two lines in question. By applying the test to QTL data simulated under selection, we demonstrate that conditioning on the phenotypic difference results in a loss of power to reject the neutral hypothesis and marked sensitivity to variation in locus effect magnitude.
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spelling pubmed-34112462012-08-20 Resampling QTL Effects in the QTL Sign Test Leads to Incongruous Sensitivity to Variance in Effect Size Rice, Daniel P. Townsend, Jeffrey P. G3 (Bethesda) Investigations Allelic effects at quantitative trait loci (QTL) between lineages are potentially informative for indicating the action of natural selection. The QTL Sign Test uses the number of + and − alleles observed in a QTL study to infer a history of selection. This test has been constructed to condition on the phenotypic difference between the two lines in question. By applying the test to QTL data simulated under selection, we demonstrate that conditioning on the phenotypic difference results in a loss of power to reject the neutral hypothesis and marked sensitivity to variation in locus effect magnitude. Genetics Society of America 2012-08-01 /pmc/articles/PMC3411246/ /pubmed/22908039 http://dx.doi.org/10.1534/g3.112.003228 Text en Copyright © 2012 Rice, Townsend http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Unported License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Investigations
Rice, Daniel P.
Townsend, Jeffrey P.
Resampling QTL Effects in the QTL Sign Test Leads to Incongruous Sensitivity to Variance in Effect Size
title Resampling QTL Effects in the QTL Sign Test Leads to Incongruous Sensitivity to Variance in Effect Size
title_full Resampling QTL Effects in the QTL Sign Test Leads to Incongruous Sensitivity to Variance in Effect Size
title_fullStr Resampling QTL Effects in the QTL Sign Test Leads to Incongruous Sensitivity to Variance in Effect Size
title_full_unstemmed Resampling QTL Effects in the QTL Sign Test Leads to Incongruous Sensitivity to Variance in Effect Size
title_short Resampling QTL Effects in the QTL Sign Test Leads to Incongruous Sensitivity to Variance in Effect Size
title_sort resampling qtl effects in the qtl sign test leads to incongruous sensitivity to variance in effect size
topic Investigations
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411246/
https://www.ncbi.nlm.nih.gov/pubmed/22908039
http://dx.doi.org/10.1534/g3.112.003228
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