Loss of a 20S Proteasome Activator in Saccharomyces cerevisiae Downregulates Genes Important for Genomic Integrity, Increases DNA Damage, and Selectively Sensitizes Cells to Agents With Diverse Mechanisms of Action

Cytoprotective functions of a 20S proteasome activator were investigated. Saccharomyces cerevisiae Blm10 and human 20S proteasome activator 200 (PA200) are homologs. Comparative genome-wide analyses of untreated diploid cells lacking Blm10 and growing at steady state at defined growth rates revealed...

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Detalles Bibliográficos
Autores principales: Doherty, Kevin M., Pride, Leah D., Lukose, James, Snydsman, Brian E., Charles, Ronald, Pramanik, Ajay, Muller, Eric G., Botstein, David, Moore, Carol Wood
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2012
Materias:
Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411250/
https://www.ncbi.nlm.nih.gov/pubmed/22908043
http://dx.doi.org/10.1534/g3.112.003376

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