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Pharmacokinetics and Toxicity in Rats and Monkeys of coDbait: A Therapeutic Double-stranded DNA Oligonucleotide Conjugated to Cholesterol

Increased DNA repair activity in cancer cells is one of their primary mechanisms of resistance to current radio- and chemotherapies. The molecule coDbait is the first candidate in a new class of drugs that target the double-strand DNA break repair pathways with the aim of overcoming these resistance...

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Detalles Bibliográficos
Autores principales:	Schlegel, Anne, Buhler, Cyril, Devun, Flavien, Agrario, Céline, Urien, Saïk, Lokiec, François, Sun, Jian-Sheng, Dutreix, Marie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2012
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411319/ https://www.ncbi.nlm.nih.gov/pubmed/23344149 http://dx.doi.org/10.1038/mtna.2012.27

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