Omentin as a novel biomarker of metabolic risk factors

BACKGROUND: Omentin is an adipocytokine that is abundantly expressed in visceral fat tissue. We investigated the association of omentin with the number of metabolic risk factors. FINDING: The study population comprised 201 Japanese men who underwent annual health checkups. Plasma omentin levels were...

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Autores principales: Shibata, Rei, Ouchi, Noriyuki, Takahashi, Ryotaro, Terakura, Yuya, Ohashi, Koji, Ikeda, Nobuo, Higuchi, Akiko, Terasaki, Hiroko, Kihara, Shinji, Murohara, Toyoaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411496/
https://www.ncbi.nlm.nih.gov/pubmed/22835063
http://dx.doi.org/10.1186/1758-5996-4-37
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author Shibata, Rei
Ouchi, Noriyuki
Takahashi, Ryotaro
Terakura, Yuya
Ohashi, Koji
Ikeda, Nobuo
Higuchi, Akiko
Terasaki, Hiroko
Kihara, Shinji
Murohara, Toyoaki
author_facet Shibata, Rei
Ouchi, Noriyuki
Takahashi, Ryotaro
Terakura, Yuya
Ohashi, Koji
Ikeda, Nobuo
Higuchi, Akiko
Terasaki, Hiroko
Kihara, Shinji
Murohara, Toyoaki
author_sort Shibata, Rei
collection PubMed
description BACKGROUND: Omentin is an adipocytokine that is abundantly expressed in visceral fat tissue. We investigated the association of omentin with the number of metabolic risk factors. FINDING: The study population comprised 201 Japanese men who underwent annual health checkups. Plasma omentin levels were determined by enzyme-linked immunosorbent assay. We divided the subjects into 4 groups according to omentin levels. A reduction of plasma omentin levels significantly correlated with an increase in the mean number of metabolic risk factors such as increased waist circumference, dyslipidemia, high blood pressure and glucose intolerance. CONCLUSIONS: Circulating omentin levels negatively correlated with the multiplicity of metabolic risk factors, suggesting that omentin acts as a biomarker of metabolic disorders.
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spelling pubmed-34114962012-08-04 Omentin as a novel biomarker of metabolic risk factors Shibata, Rei Ouchi, Noriyuki Takahashi, Ryotaro Terakura, Yuya Ohashi, Koji Ikeda, Nobuo Higuchi, Akiko Terasaki, Hiroko Kihara, Shinji Murohara, Toyoaki Diabetol Metab Syndr Short Report BACKGROUND: Omentin is an adipocytokine that is abundantly expressed in visceral fat tissue. We investigated the association of omentin with the number of metabolic risk factors. FINDING: The study population comprised 201 Japanese men who underwent annual health checkups. Plasma omentin levels were determined by enzyme-linked immunosorbent assay. We divided the subjects into 4 groups according to omentin levels. A reduction of plasma omentin levels significantly correlated with an increase in the mean number of metabolic risk factors such as increased waist circumference, dyslipidemia, high blood pressure and glucose intolerance. CONCLUSIONS: Circulating omentin levels negatively correlated with the multiplicity of metabolic risk factors, suggesting that omentin acts as a biomarker of metabolic disorders. BioMed Central 2012-07-26 /pmc/articles/PMC3411496/ /pubmed/22835063 http://dx.doi.org/10.1186/1758-5996-4-37 Text en Copyright ©2012 Shibata et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Report
Shibata, Rei
Ouchi, Noriyuki
Takahashi, Ryotaro
Terakura, Yuya
Ohashi, Koji
Ikeda, Nobuo
Higuchi, Akiko
Terasaki, Hiroko
Kihara, Shinji
Murohara, Toyoaki
Omentin as a novel biomarker of metabolic risk factors
title Omentin as a novel biomarker of metabolic risk factors
title_full Omentin as a novel biomarker of metabolic risk factors
title_fullStr Omentin as a novel biomarker of metabolic risk factors
title_full_unstemmed Omentin as a novel biomarker of metabolic risk factors
title_short Omentin as a novel biomarker of metabolic risk factors
title_sort omentin as a novel biomarker of metabolic risk factors
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411496/
https://www.ncbi.nlm.nih.gov/pubmed/22835063
http://dx.doi.org/10.1186/1758-5996-4-37
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