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Ocular melanoma in a patient successfully treated for diffuse malignant peritoneal mesothelioma: a case report

BACKGROUND: Diffuse malignant peritoneal mesothelioma and ocular melanoma are both rare tumors. To the best of our knowledge there is only one previous report of three cases in a family with known susceptibility to malignancies associating diffuse malignant peritoneal mesothelioma and ocular melanom...

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Autores principales: Langlais, Sara, Velazquez-Martin, Juan Pablo, Dubé, Pierre, Simpson, Ernest Rand, Leblanc, Guy, Sideris, Lucas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411503/
https://www.ncbi.nlm.nih.gov/pubmed/22613358
http://dx.doi.org/10.1186/1477-7819-10-90
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author Langlais, Sara
Velazquez-Martin, Juan Pablo
Dubé, Pierre
Simpson, Ernest Rand
Leblanc, Guy
Sideris, Lucas
author_facet Langlais, Sara
Velazquez-Martin, Juan Pablo
Dubé, Pierre
Simpson, Ernest Rand
Leblanc, Guy
Sideris, Lucas
author_sort Langlais, Sara
collection PubMed
description BACKGROUND: Diffuse malignant peritoneal mesothelioma and ocular melanoma are both rare tumors. To the best of our knowledge there is only one previous report of three cases in a family with known susceptibility to malignancies associating diffuse malignant peritoneal mesothelioma and ocular melanoma, with no sporadic cases previously reported. CASE PRESENTATION: We describe the case of a 59-year-old man with a history of diffuse malignant peritoneal mesothelioma, who presented with ocular melanoma 41 months after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. We also briefly review the literature. CONCLUSIONS: Diffuse malignant peritoneal mesothelioma is an uncommon but aggressive disease. As diffuse malignant peritoneal mesothelioma characteristically remains confined to the abdominal cavity, any new extra-abdominal symptom should eventually raise suspicion of another primary tumor. Few cases of diffuse malignant peritoneal mesothelioma associated with other primary tumors have been reported. As ocular melanoma is also infrequent, we suspect a genetic predisposition to these tumors. There is emerging evidence supporting the role of BAP1 mutations in the pathogenesis of these two neoplasias.
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spelling pubmed-34115032012-08-04 Ocular melanoma in a patient successfully treated for diffuse malignant peritoneal mesothelioma: a case report Langlais, Sara Velazquez-Martin, Juan Pablo Dubé, Pierre Simpson, Ernest Rand Leblanc, Guy Sideris, Lucas World J Surg Oncol Case Report BACKGROUND: Diffuse malignant peritoneal mesothelioma and ocular melanoma are both rare tumors. To the best of our knowledge there is only one previous report of three cases in a family with known susceptibility to malignancies associating diffuse malignant peritoneal mesothelioma and ocular melanoma, with no sporadic cases previously reported. CASE PRESENTATION: We describe the case of a 59-year-old man with a history of diffuse malignant peritoneal mesothelioma, who presented with ocular melanoma 41 months after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. We also briefly review the literature. CONCLUSIONS: Diffuse malignant peritoneal mesothelioma is an uncommon but aggressive disease. As diffuse malignant peritoneal mesothelioma characteristically remains confined to the abdominal cavity, any new extra-abdominal symptom should eventually raise suspicion of another primary tumor. Few cases of diffuse malignant peritoneal mesothelioma associated with other primary tumors have been reported. As ocular melanoma is also infrequent, we suspect a genetic predisposition to these tumors. There is emerging evidence supporting the role of BAP1 mutations in the pathogenesis of these two neoplasias. BioMed Central 2012-05-21 /pmc/articles/PMC3411503/ /pubmed/22613358 http://dx.doi.org/10.1186/1477-7819-10-90 Text en Copyright ©2012 Langlais et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Langlais, Sara
Velazquez-Martin, Juan Pablo
Dubé, Pierre
Simpson, Ernest Rand
Leblanc, Guy
Sideris, Lucas
Ocular melanoma in a patient successfully treated for diffuse malignant peritoneal mesothelioma: a case report
title Ocular melanoma in a patient successfully treated for diffuse malignant peritoneal mesothelioma: a case report
title_full Ocular melanoma in a patient successfully treated for diffuse malignant peritoneal mesothelioma: a case report
title_fullStr Ocular melanoma in a patient successfully treated for diffuse malignant peritoneal mesothelioma: a case report
title_full_unstemmed Ocular melanoma in a patient successfully treated for diffuse malignant peritoneal mesothelioma: a case report
title_short Ocular melanoma in a patient successfully treated for diffuse malignant peritoneal mesothelioma: a case report
title_sort ocular melanoma in a patient successfully treated for diffuse malignant peritoneal mesothelioma: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411503/
https://www.ncbi.nlm.nih.gov/pubmed/22613358
http://dx.doi.org/10.1186/1477-7819-10-90
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