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Ocular melanoma in a patient successfully treated for diffuse malignant peritoneal mesothelioma: a case report
BACKGROUND: Diffuse malignant peritoneal mesothelioma and ocular melanoma are both rare tumors. To the best of our knowledge there is only one previous report of three cases in a family with known susceptibility to malignancies associating diffuse malignant peritoneal mesothelioma and ocular melanom...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411503/ https://www.ncbi.nlm.nih.gov/pubmed/22613358 http://dx.doi.org/10.1186/1477-7819-10-90 |
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author | Langlais, Sara Velazquez-Martin, Juan Pablo Dubé, Pierre Simpson, Ernest Rand Leblanc, Guy Sideris, Lucas |
author_facet | Langlais, Sara Velazquez-Martin, Juan Pablo Dubé, Pierre Simpson, Ernest Rand Leblanc, Guy Sideris, Lucas |
author_sort | Langlais, Sara |
collection | PubMed |
description | BACKGROUND: Diffuse malignant peritoneal mesothelioma and ocular melanoma are both rare tumors. To the best of our knowledge there is only one previous report of three cases in a family with known susceptibility to malignancies associating diffuse malignant peritoneal mesothelioma and ocular melanoma, with no sporadic cases previously reported. CASE PRESENTATION: We describe the case of a 59-year-old man with a history of diffuse malignant peritoneal mesothelioma, who presented with ocular melanoma 41 months after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. We also briefly review the literature. CONCLUSIONS: Diffuse malignant peritoneal mesothelioma is an uncommon but aggressive disease. As diffuse malignant peritoneal mesothelioma characteristically remains confined to the abdominal cavity, any new extra-abdominal symptom should eventually raise suspicion of another primary tumor. Few cases of diffuse malignant peritoneal mesothelioma associated with other primary tumors have been reported. As ocular melanoma is also infrequent, we suspect a genetic predisposition to these tumors. There is emerging evidence supporting the role of BAP1 mutations in the pathogenesis of these two neoplasias. |
format | Online Article Text |
id | pubmed-3411503 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-34115032012-08-04 Ocular melanoma in a patient successfully treated for diffuse malignant peritoneal mesothelioma: a case report Langlais, Sara Velazquez-Martin, Juan Pablo Dubé, Pierre Simpson, Ernest Rand Leblanc, Guy Sideris, Lucas World J Surg Oncol Case Report BACKGROUND: Diffuse malignant peritoneal mesothelioma and ocular melanoma are both rare tumors. To the best of our knowledge there is only one previous report of three cases in a family with known susceptibility to malignancies associating diffuse malignant peritoneal mesothelioma and ocular melanoma, with no sporadic cases previously reported. CASE PRESENTATION: We describe the case of a 59-year-old man with a history of diffuse malignant peritoneal mesothelioma, who presented with ocular melanoma 41 months after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. We also briefly review the literature. CONCLUSIONS: Diffuse malignant peritoneal mesothelioma is an uncommon but aggressive disease. As diffuse malignant peritoneal mesothelioma characteristically remains confined to the abdominal cavity, any new extra-abdominal symptom should eventually raise suspicion of another primary tumor. Few cases of diffuse malignant peritoneal mesothelioma associated with other primary tumors have been reported. As ocular melanoma is also infrequent, we suspect a genetic predisposition to these tumors. There is emerging evidence supporting the role of BAP1 mutations in the pathogenesis of these two neoplasias. BioMed Central 2012-05-21 /pmc/articles/PMC3411503/ /pubmed/22613358 http://dx.doi.org/10.1186/1477-7819-10-90 Text en Copyright ©2012 Langlais et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Langlais, Sara Velazquez-Martin, Juan Pablo Dubé, Pierre Simpson, Ernest Rand Leblanc, Guy Sideris, Lucas Ocular melanoma in a patient successfully treated for diffuse malignant peritoneal mesothelioma: a case report |
title | Ocular melanoma in a patient successfully treated for diffuse malignant peritoneal mesothelioma: a case report |
title_full | Ocular melanoma in a patient successfully treated for diffuse malignant peritoneal mesothelioma: a case report |
title_fullStr | Ocular melanoma in a patient successfully treated for diffuse malignant peritoneal mesothelioma: a case report |
title_full_unstemmed | Ocular melanoma in a patient successfully treated for diffuse malignant peritoneal mesothelioma: a case report |
title_short | Ocular melanoma in a patient successfully treated for diffuse malignant peritoneal mesothelioma: a case report |
title_sort | ocular melanoma in a patient successfully treated for diffuse malignant peritoneal mesothelioma: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411503/ https://www.ncbi.nlm.nih.gov/pubmed/22613358 http://dx.doi.org/10.1186/1477-7819-10-90 |
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