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Evidence that the Density of Self Peptide-MHC Ligands Regulates T-Cell Receptor Signaling

Noncognate or self peptide-MHC (pMHC) ligands productively interact with T-cell receptor (TCR) and are always in a large access over the cognate pMHC on the surface of antigen presenting cells. We assembled soluble cognate and noncognate pMHC class I (pMHC-I) ligands at designated ratios on various...

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Detalles Bibliográficos
Autores principales:	Anikeeva, Nadia, Gakamsky, Dimitry, Schøller, Jørgen, Sykulev, Yuri
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411518/ https://www.ncbi.nlm.nih.gov/pubmed/22870225 http://dx.doi.org/10.1371/journal.pone.0041466

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