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Involvement of Calpain/p35-p25/Cdk5/NMDAR Signaling Pathway in Glutamate-Induced Neurotoxicity in Cultured Rat Retinal Neurons

We investigated possible involvement of a calpain/p35-p25/cyclin-dependent kinase 5 (Cdk5) signaling pathway in modifying NMDA receptors (NMDARs) in glutamate-induced injury of cultured rat retinal neurons. Glutamate treatment decreased cell viability and induced cell apoptosis, which was accompanie...

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Detalles Bibliográficos
Autores principales:	Miao, Yanying, Dong, Ling-Dan, Chen, Jie, Hu, Xiao-Chen, Yang, Xiong-Li, Wang, Zhongfeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411656/ https://www.ncbi.nlm.nih.gov/pubmed/22870316 http://dx.doi.org/10.1371/journal.pone.0042318

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