Rapid Detection of an ABT-737-Sensitive Primed for Death State in Cells Using Microplate-Based Respirometry

Cells that exhibit an absolute dependence on the anti-apoptotic BCL-2 protein for survival are termed “primed for death” and are killed by the BCL-2 antagonist ABT-737. Many cancers exhibit a primed phenotype, including some that are resistant to conventional chemotherapy due to high BCL-2 expressio...

Descripción completa

Detalles Bibliográficos
Autores principales: Clerc, Pascaline, Carey, Gregory B., Mehrabian, Zara, Wei, Michael, Hwang, Hyehyun, Girnun, Geoffrey D., Chen, Hegang, Martin, Stuart S., Polster, Brian M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411749/
https://www.ncbi.nlm.nih.gov/pubmed/22880001
http://dx.doi.org/10.1371/journal.pone.0042487

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411749/
https://www.ncbi.nlm.nih.gov/pubmed/22880001
http://dx.doi.org/10.1371/journal.pone.0042487

Ejemplares similares