Cargando…
Melanopsin Mediates Retrograde Visual Signaling in the Retina
The canonical flow of visual signals proceeds from outer to inner retina (photoreceptors→bipolar cells→ganglion cells). However, melanopsin-expressing ganglion cells are photosensitive and functional sustained light signaling to retinal dopaminergic interneurons persists in the absence of rods and c...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411794/ https://www.ncbi.nlm.nih.gov/pubmed/22880066 http://dx.doi.org/10.1371/journal.pone.0042647 |
_version_ | 1782239899779334144 |
---|---|
author | Zhang, Dao-Qi Belenky, Michael A. Sollars, Patricia J. Pickard, Gary E. McMahon, Douglas G. |
author_facet | Zhang, Dao-Qi Belenky, Michael A. Sollars, Patricia J. Pickard, Gary E. McMahon, Douglas G. |
author_sort | Zhang, Dao-Qi |
collection | PubMed |
description | The canonical flow of visual signals proceeds from outer to inner retina (photoreceptors→bipolar cells→ganglion cells). However, melanopsin-expressing ganglion cells are photosensitive and functional sustained light signaling to retinal dopaminergic interneurons persists in the absence of rods and cones. Here we show that the sustained-type light response of retinal dopamine neurons requires melanopsin and that the response is mediated by AMPA-type glutamate receptors, defining a retrograde retinal visual signaling pathway that fully reverses the usual flow of light signals in retinal circuits. |
format | Online Article Text |
id | pubmed-3411794 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-34117942012-08-09 Melanopsin Mediates Retrograde Visual Signaling in the Retina Zhang, Dao-Qi Belenky, Michael A. Sollars, Patricia J. Pickard, Gary E. McMahon, Douglas G. PLoS One Research Article The canonical flow of visual signals proceeds from outer to inner retina (photoreceptors→bipolar cells→ganglion cells). However, melanopsin-expressing ganglion cells are photosensitive and functional sustained light signaling to retinal dopaminergic interneurons persists in the absence of rods and cones. Here we show that the sustained-type light response of retinal dopamine neurons requires melanopsin and that the response is mediated by AMPA-type glutamate receptors, defining a retrograde retinal visual signaling pathway that fully reverses the usual flow of light signals in retinal circuits. Public Library of Science 2012-08-03 /pmc/articles/PMC3411794/ /pubmed/22880066 http://dx.doi.org/10.1371/journal.pone.0042647 Text en © 2012 Zhang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Zhang, Dao-Qi Belenky, Michael A. Sollars, Patricia J. Pickard, Gary E. McMahon, Douglas G. Melanopsin Mediates Retrograde Visual Signaling in the Retina |
title | Melanopsin Mediates Retrograde Visual Signaling in the Retina |
title_full | Melanopsin Mediates Retrograde Visual Signaling in the Retina |
title_fullStr | Melanopsin Mediates Retrograde Visual Signaling in the Retina |
title_full_unstemmed | Melanopsin Mediates Retrograde Visual Signaling in the Retina |
title_short | Melanopsin Mediates Retrograde Visual Signaling in the Retina |
title_sort | melanopsin mediates retrograde visual signaling in the retina |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411794/ https://www.ncbi.nlm.nih.gov/pubmed/22880066 http://dx.doi.org/10.1371/journal.pone.0042647 |
work_keys_str_mv | AT zhangdaoqi melanopsinmediatesretrogradevisualsignalingintheretina AT belenkymichaela melanopsinmediatesretrogradevisualsignalingintheretina AT sollarspatriciaj melanopsinmediatesretrogradevisualsignalingintheretina AT pickardgarye melanopsinmediatesretrogradevisualsignalingintheretina AT mcmahondouglasg melanopsinmediatesretrogradevisualsignalingintheretina |