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Targeted Deletion of Kcne2 Impairs HCN Channel Function in Mouse Thalamocortical Circuits

BACKGROUND: Hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels generate the pacemaking current, I(h), which regulates neuronal excitability, burst firing activity, rhythmogenesis, and synaptic integration. The physiological consequence of HCN activation depends on regulation of chan...

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Detalles Bibliográficos
Autores principales:	Ying, Shui-Wang, Kanda, Vikram A., Hu, Zhaoyang, Purtell, Kerry, King, Elizabeth C., Abbott, Geoffrey W., Goldstein, Peter A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411840/ https://www.ncbi.nlm.nih.gov/pubmed/22880098 http://dx.doi.org/10.1371/journal.pone.0042756

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