Corticostriatal functional connectivity predicts transition to chronic back pain

The mechanism of brain reorganization in pain chronification is unknown. In a longitudinal brain imaging study, sub–acute back pain (SBP) patients were followed over one year. When pain persisted (SBPp, in contrast to recovering SBP, and healthy controls), brain gray matter density decreased. Import...

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Detalles Bibliográficos
Autores principales: Baliki, Marwan N., Petre, Bogdan, Torbey, Souraya, Herrmann, Kristina M., Huang, Lejian, Schnitzer, Thomas J., Fields, Howard L., Apkarian, A. Vania
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411898/
https://www.ncbi.nlm.nih.gov/pubmed/22751038
http://dx.doi.org/10.1038/nn.3153
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author Baliki, Marwan N.
Petre, Bogdan
Torbey, Souraya
Herrmann, Kristina M.
Huang, Lejian
Schnitzer, Thomas J.
Fields, Howard L.
Apkarian, A. Vania
author_facet Baliki, Marwan N.
Petre, Bogdan
Torbey, Souraya
Herrmann, Kristina M.
Huang, Lejian
Schnitzer, Thomas J.
Fields, Howard L.
Apkarian, A. Vania
author_sort Baliki, Marwan N.
collection PubMed
description The mechanism of brain reorganization in pain chronification is unknown. In a longitudinal brain imaging study, sub–acute back pain (SBP) patients were followed over one year. When pain persisted (SBPp, in contrast to recovering SBP, and healthy controls), brain gray matter density decreased. Importantly, initially greater functional connectivity of nucleus accumbens with prefrontal cortex predicted pain persistence, implying that corticostriatal circuitry is causally involved in the transition from acute to chronic pain.
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spelling pubmed-34118982013-02-01 Corticostriatal functional connectivity predicts transition to chronic back pain Baliki, Marwan N. Petre, Bogdan Torbey, Souraya Herrmann, Kristina M. Huang, Lejian Schnitzer, Thomas J. Fields, Howard L. Apkarian, A. Vania Nat Neurosci Article The mechanism of brain reorganization in pain chronification is unknown. In a longitudinal brain imaging study, sub–acute back pain (SBP) patients were followed over one year. When pain persisted (SBPp, in contrast to recovering SBP, and healthy controls), brain gray matter density decreased. Importantly, initially greater functional connectivity of nucleus accumbens with prefrontal cortex predicted pain persistence, implying that corticostriatal circuitry is causally involved in the transition from acute to chronic pain. 2012-07-01 /pmc/articles/PMC3411898/ /pubmed/22751038 http://dx.doi.org/10.1038/nn.3153 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Baliki, Marwan N.
Petre, Bogdan
Torbey, Souraya
Herrmann, Kristina M.
Huang, Lejian
Schnitzer, Thomas J.
Fields, Howard L.
Apkarian, A. Vania
Corticostriatal functional connectivity predicts transition to chronic back pain
title Corticostriatal functional connectivity predicts transition to chronic back pain
title_full Corticostriatal functional connectivity predicts transition to chronic back pain
title_fullStr Corticostriatal functional connectivity predicts transition to chronic back pain
title_full_unstemmed Corticostriatal functional connectivity predicts transition to chronic back pain
title_short Corticostriatal functional connectivity predicts transition to chronic back pain
title_sort corticostriatal functional connectivity predicts transition to chronic back pain
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411898/
https://www.ncbi.nlm.nih.gov/pubmed/22751038
http://dx.doi.org/10.1038/nn.3153
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