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Bone Demineralization in Postmenopausal Women: Role of Anamnestic Risk Factors
This study evaluated the effects of LT4 administration on the bone mineral density (BMD) in physiological postmenopausal women after two years of continuative treatment. 110 postmenopausal women with nodular goiter aged between 50 and 55 years were examined before and after 2 years of therapy with a...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412114/ https://www.ncbi.nlm.nih.gov/pubmed/22899918 http://dx.doi.org/10.1155/2012/837187 |
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author | La Vignera, Sandro Condorelli, Rosita A. Vicari, Enzo Nicoletti, Chiara Calogero, Aldo E. |
author_facet | La Vignera, Sandro Condorelli, Rosita A. Vicari, Enzo Nicoletti, Chiara Calogero, Aldo E. |
author_sort | La Vignera, Sandro |
collection | PubMed |
description | This study evaluated the effects of LT4 administration on the bone mineral density (BMD) in physiological postmenopausal women after two years of continuative treatment. 110 postmenopausal women with nodular goiter aged between 50 and 55 years were examined before and after 2 years of therapy with a fixed dose of LT4 (1.6 mcg/kg/die) for the treatment of nodular thyroid disease. The results showed that the patients on treatment with LT4 have a slight, but significant reduction of the BMD after 2 years of treatment, associated with increased serum levels of alkaline phosphatase and urinary excretion of hydroxyproline, confirming our data conducted on the same group after one year of therapy. Comparison between patients receiving LT4 (group A) or not (group B) showed that group A patients had significantly lower BMD. We demonstrated the statistically significant influence of the following risk factors on BMD: (1) body mass index <19 kg/m(2); (2) the onset of menarche after the age of 15 years; (3) positive history for period of amenorrhoea; (4) nulliparity. |
format | Online Article Text |
id | pubmed-3412114 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-34121142012-08-16 Bone Demineralization in Postmenopausal Women: Role of Anamnestic Risk Factors La Vignera, Sandro Condorelli, Rosita A. Vicari, Enzo Nicoletti, Chiara Calogero, Aldo E. Int J Endocrinol Clinical Study This study evaluated the effects of LT4 administration on the bone mineral density (BMD) in physiological postmenopausal women after two years of continuative treatment. 110 postmenopausal women with nodular goiter aged between 50 and 55 years were examined before and after 2 years of therapy with a fixed dose of LT4 (1.6 mcg/kg/die) for the treatment of nodular thyroid disease. The results showed that the patients on treatment with LT4 have a slight, but significant reduction of the BMD after 2 years of treatment, associated with increased serum levels of alkaline phosphatase and urinary excretion of hydroxyproline, confirming our data conducted on the same group after one year of therapy. Comparison between patients receiving LT4 (group A) or not (group B) showed that group A patients had significantly lower BMD. We demonstrated the statistically significant influence of the following risk factors on BMD: (1) body mass index <19 kg/m(2); (2) the onset of menarche after the age of 15 years; (3) positive history for period of amenorrhoea; (4) nulliparity. Hindawi Publishing Corporation 2012 2012-07-26 /pmc/articles/PMC3412114/ /pubmed/22899918 http://dx.doi.org/10.1155/2012/837187 Text en Copyright © 2012 Sandro La Vignera et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study La Vignera, Sandro Condorelli, Rosita A. Vicari, Enzo Nicoletti, Chiara Calogero, Aldo E. Bone Demineralization in Postmenopausal Women: Role of Anamnestic Risk Factors |
title | Bone Demineralization in Postmenopausal Women: Role of Anamnestic Risk Factors |
title_full | Bone Demineralization in Postmenopausal Women: Role of Anamnestic Risk Factors |
title_fullStr | Bone Demineralization in Postmenopausal Women: Role of Anamnestic Risk Factors |
title_full_unstemmed | Bone Demineralization in Postmenopausal Women: Role of Anamnestic Risk Factors |
title_short | Bone Demineralization in Postmenopausal Women: Role of Anamnestic Risk Factors |
title_sort | bone demineralization in postmenopausal women: role of anamnestic risk factors |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412114/ https://www.ncbi.nlm.nih.gov/pubmed/22899918 http://dx.doi.org/10.1155/2012/837187 |
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