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Mercury Disposition in Suckling Rats: Comparative Assessment Following Parenteral Exposure to Thiomersal and Mercuric Chloride

Due to the facts that thiomersal-containing vaccine is still in use in many developing countries, and all forms of mercury have recognised neurotoxic, nephrotoxic, and other toxic effects, studies on disposition of ethylmercury and other mercury forms are still justified, especially at young age. Ou...

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Autores principales: Blanuša, Maja, Orct, Tatjana, Vihnanek Lazarus, Maja, Sekovanić, Ankica, Piasek, Martina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412121/
https://www.ncbi.nlm.nih.gov/pubmed/22899883
http://dx.doi.org/10.1155/2012/256965
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author Blanuša, Maja
Orct, Tatjana
Vihnanek Lazarus, Maja
Sekovanić, Ankica
Piasek, Martina
author_facet Blanuša, Maja
Orct, Tatjana
Vihnanek Lazarus, Maja
Sekovanić, Ankica
Piasek, Martina
author_sort Blanuša, Maja
collection PubMed
description Due to the facts that thiomersal-containing vaccine is still in use in many developing countries, and all forms of mercury have recognised neurotoxic, nephrotoxic, and other toxic effects, studies on disposition of ethylmercury and other mercury forms are still justified, especially at young age. Our investigation aimed at comparing mercury distribution and rate of excretion in the early period of life following exposure to either thiomersal (TM) or mercuric chloride (HgCl(2)) in suckling rats. Three experimental groups were studied: control, TM, and HgCl(2), with 12 to18 pups in each. Both forms of mercury were administered subcutaneously in equimolar quantities (0.81 μmol/kg b.w.) three times during the suckling period (on the days of birth 7, 9, and 11) to mimic the vaccination regimen in infants. After the last administration of TM or HgCl(2), total mercury retention and excretion was assessed during following six days. In TM-exposed group mercury retention was higher in the brain, enteral excretion was similar, and urinary excretion was much lower compared to HgCl(2)-exposed sucklings. More research is still needed to elucidate all aspects of toxicokinetics and most harmful neurotoxic potential of various forms of mercury, especially in the earliest period of life.
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spelling pubmed-34121212012-08-16 Mercury Disposition in Suckling Rats: Comparative Assessment Following Parenteral Exposure to Thiomersal and Mercuric Chloride Blanuša, Maja Orct, Tatjana Vihnanek Lazarus, Maja Sekovanić, Ankica Piasek, Martina J Biomed Biotechnol Research Article Due to the facts that thiomersal-containing vaccine is still in use in many developing countries, and all forms of mercury have recognised neurotoxic, nephrotoxic, and other toxic effects, studies on disposition of ethylmercury and other mercury forms are still justified, especially at young age. Our investigation aimed at comparing mercury distribution and rate of excretion in the early period of life following exposure to either thiomersal (TM) or mercuric chloride (HgCl(2)) in suckling rats. Three experimental groups were studied: control, TM, and HgCl(2), with 12 to18 pups in each. Both forms of mercury were administered subcutaneously in equimolar quantities (0.81 μmol/kg b.w.) three times during the suckling period (on the days of birth 7, 9, and 11) to mimic the vaccination regimen in infants. After the last administration of TM or HgCl(2), total mercury retention and excretion was assessed during following six days. In TM-exposed group mercury retention was higher in the brain, enteral excretion was similar, and urinary excretion was much lower compared to HgCl(2)-exposed sucklings. More research is still needed to elucidate all aspects of toxicokinetics and most harmful neurotoxic potential of various forms of mercury, especially in the earliest period of life. Hindawi Publishing Corporation 2012 2012-07-26 /pmc/articles/PMC3412121/ /pubmed/22899883 http://dx.doi.org/10.1155/2012/256965 Text en Copyright © 2012 Maja Blanuša et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Blanuša, Maja
Orct, Tatjana
Vihnanek Lazarus, Maja
Sekovanić, Ankica
Piasek, Martina
Mercury Disposition in Suckling Rats: Comparative Assessment Following Parenteral Exposure to Thiomersal and Mercuric Chloride
title Mercury Disposition in Suckling Rats: Comparative Assessment Following Parenteral Exposure to Thiomersal and Mercuric Chloride
title_full Mercury Disposition in Suckling Rats: Comparative Assessment Following Parenteral Exposure to Thiomersal and Mercuric Chloride
title_fullStr Mercury Disposition in Suckling Rats: Comparative Assessment Following Parenteral Exposure to Thiomersal and Mercuric Chloride
title_full_unstemmed Mercury Disposition in Suckling Rats: Comparative Assessment Following Parenteral Exposure to Thiomersal and Mercuric Chloride
title_short Mercury Disposition in Suckling Rats: Comparative Assessment Following Parenteral Exposure to Thiomersal and Mercuric Chloride
title_sort mercury disposition in suckling rats: comparative assessment following parenteral exposure to thiomersal and mercuric chloride
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412121/
https://www.ncbi.nlm.nih.gov/pubmed/22899883
http://dx.doi.org/10.1155/2012/256965
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