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Activation of the AKT/cyclin D1/Cdk4 survival signaling pathway in radioresistant cancer stem cells

Radioresistance, which is a major cause of failure of radiotherapy (RT), is proposed as one of the intrinsic characteristics of cancer stem cells (CSCs) whose unique DNA damage response (DDR), efficient DNA repair and resistance to apoptosis are thought to confer the phenotype. We have isolated surv...

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Detalles Bibliográficos
Autores principales:	Shimura, T, Noma, N, Oikawa, T, Ochiai, Y, Kakuda, S, Kuwahara, Y, Takai, Y, Takahashi, A, Fukumoto, M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2012
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412645/ https://www.ncbi.nlm.nih.gov/pubmed/23552696 http://dx.doi.org/10.1038/oncsis.2012.12

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