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The Effect of Polyp Location and Patient Gender on the Presence of Dysplasia in Colonic Polyps

OBJECTIVE: There is increasing evidence of significant clinical and biological differences between proximal and distal colorectal polyps, as well as possible differences based on patient gender. There is a need to optimize and individualize screening strategies. We studied the potential influence of...

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Autores principales: Qumseya, Bashar J, Coe, Susan, Wallace, Michael B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412677/
https://www.ncbi.nlm.nih.gov/pubmed/23238292
http://dx.doi.org/10.1038/ctg.2012.14
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author Qumseya, Bashar J
Coe, Susan
Wallace, Michael B
author_facet Qumseya, Bashar J
Coe, Susan
Wallace, Michael B
author_sort Qumseya, Bashar J
collection PubMed
description OBJECTIVE: There is increasing evidence of significant clinical and biological differences between proximal and distal colorectal polyps, as well as possible differences based on patient gender. There is a need to optimize and individualize screening strategies. We studied the potential influence of gender and of polyp location on the presence of dysplasia in colon polyps. METHODS: We used a prospective database on adenoma detection to identify patients. The primary outcome was the presence of dysplasia in colonic polyps. Covariates include age, gender, race, lesion size and site, and use of aspirin. Multivariate logistic regression analysis was used to analyze the relationship between the primary outcome and covariates. Results were reported as odds ratios (ORs), 95% confidence intervals (CIs), and P-values. RESULTS: A total of 2,400 patients (50.5% females and 49.5% males) completed colonoscopy for various indications. A total of 3,045 polyps were removed in 1,237 patients. Of those polyps, 54% (n=1,636) were on the right compared with 46% (n=1,409) in the left colon. The proportion of adenomas was significantly greater on the right colon when compared with the left: 69.4% vs. 39.3% (P=<0.0001). Multivariate logistic regression analysis showed that the right colon did have a significant association with dysplasia when controlling for age, gender, polyp size, and use of aspirin (OR=3.1 (95% CI: 2.3–4), P=<0.0001). Female gender was associated with decreased odds of finding dysplasia (OR=0.6 (95% CI: 0.46–0.78), P=0.03). CONCLUSION: Patient characteristics (male gender) as well procedure findings (increase polyp size and right-sided lesions) are associated with increased odds of dysplasia.
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spelling pubmed-34126772012-08-07 The Effect of Polyp Location and Patient Gender on the Presence of Dysplasia in Colonic Polyps Qumseya, Bashar J Coe, Susan Wallace, Michael B Clin Transl Gastroenterol Colon/Small Bowel OBJECTIVE: There is increasing evidence of significant clinical and biological differences between proximal and distal colorectal polyps, as well as possible differences based on patient gender. There is a need to optimize and individualize screening strategies. We studied the potential influence of gender and of polyp location on the presence of dysplasia in colon polyps. METHODS: We used a prospective database on adenoma detection to identify patients. The primary outcome was the presence of dysplasia in colonic polyps. Covariates include age, gender, race, lesion size and site, and use of aspirin. Multivariate logistic regression analysis was used to analyze the relationship between the primary outcome and covariates. Results were reported as odds ratios (ORs), 95% confidence intervals (CIs), and P-values. RESULTS: A total of 2,400 patients (50.5% females and 49.5% males) completed colonoscopy for various indications. A total of 3,045 polyps were removed in 1,237 patients. Of those polyps, 54% (n=1,636) were on the right compared with 46% (n=1,409) in the left colon. The proportion of adenomas was significantly greater on the right colon when compared with the left: 69.4% vs. 39.3% (P=<0.0001). Multivariate logistic regression analysis showed that the right colon did have a significant association with dysplasia when controlling for age, gender, polyp size, and use of aspirin (OR=3.1 (95% CI: 2.3–4), P=<0.0001). Female gender was associated with decreased odds of finding dysplasia (OR=0.6 (95% CI: 0.46–0.78), P=0.03). CONCLUSION: Patient characteristics (male gender) as well procedure findings (increase polyp size and right-sided lesions) are associated with increased odds of dysplasia. Nature Publishing Group 2012-07 2012-07-26 /pmc/articles/PMC3412677/ /pubmed/23238292 http://dx.doi.org/10.1038/ctg.2012.14 Text en Copyright © 2012 American College of Gastroenterology http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
spellingShingle Colon/Small Bowel
Qumseya, Bashar J
Coe, Susan
Wallace, Michael B
The Effect of Polyp Location and Patient Gender on the Presence of Dysplasia in Colonic Polyps
title The Effect of Polyp Location and Patient Gender on the Presence of Dysplasia in Colonic Polyps
title_full The Effect of Polyp Location and Patient Gender on the Presence of Dysplasia in Colonic Polyps
title_fullStr The Effect of Polyp Location and Patient Gender on the Presence of Dysplasia in Colonic Polyps
title_full_unstemmed The Effect of Polyp Location and Patient Gender on the Presence of Dysplasia in Colonic Polyps
title_short The Effect of Polyp Location and Patient Gender on the Presence of Dysplasia in Colonic Polyps
title_sort effect of polyp location and patient gender on the presence of dysplasia in colonic polyps
topic Colon/Small Bowel
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412677/
https://www.ncbi.nlm.nih.gov/pubmed/23238292
http://dx.doi.org/10.1038/ctg.2012.14
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