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Transient and intensive pharmacological immunosuppression fails to improve AAV-based liver gene transfer in non-human primates

BACKGROUND: Adeno-associated vectors (rAAV) have been used to attain long-term liver gene expression. In humans, the cellular immune response poses a serious obstacle for transgene persistence while neutralizing humoral immunity curtails re-administration. Porphobilinogen deaminase (PBGD) haploinsuf...

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Detalles Bibliográficos
Autores principales:	Unzu, Carmen, Hervás-Stubbs, Sandra, Sampedro, Ana, Mauleón, Itsaso, Mancheño, Uxua, Alfaro, Carlos, de Salamanca, Rafael Enríquez, Benito, Alberto, Beattie, Stuart G, Petry, Harald, Prieto, Jesús, Melero, Ignacio, Fontanellas, Antonio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412719/ https://www.ncbi.nlm.nih.gov/pubmed/22704060 http://dx.doi.org/10.1186/1479-5876-10-122

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