Cargando…

Hemoglobin A(1c) improvements and better diabetes-specific quality of life among participants completing diabetes self-management programs: A nested cohort study

BACKGROUND: Numerous primary care innovations emphasize patient-centered processes of care. Within the context of these innovations, greater understanding is needed of the relationship between improvements in clinical endpoints and patient-centered outcomes. To address this gap, we evaluated the ass...

Descripción completa

Detalles Bibliográficos
Autores principales: Khanna, Abhinav, Bush, Amber L, Swint, J Michael, Peskin, Melissa Fleschler, Street, Richard L, Naik, Aanand D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412738/
https://www.ncbi.nlm.nih.gov/pubmed/22583609
http://dx.doi.org/10.1186/1477-7525-10-48
_version_ 1782239986181996544
author Khanna, Abhinav
Bush, Amber L
Swint, J Michael
Peskin, Melissa Fleschler
Street, Richard L
Naik, Aanand D
author_facet Khanna, Abhinav
Bush, Amber L
Swint, J Michael
Peskin, Melissa Fleschler
Street, Richard L
Naik, Aanand D
author_sort Khanna, Abhinav
collection PubMed
description BACKGROUND: Numerous primary care innovations emphasize patient-centered processes of care. Within the context of these innovations, greater understanding is needed of the relationship between improvements in clinical endpoints and patient-centered outcomes. To address this gap, we evaluated the association between glycosylated hemoglobin (HbA(1c)) and diabetes-specific quality of life among patients completing diabetes self-management programs. METHODS: We conducted a retrospective cohort study nested within a randomized comparative effectiveness trial of diabetes self-management interventions in 75 diabetic patients. Multiple linear regression models were developed to examine the relationship between change in HbA(1c) from baseline to one-year follow-up and Diabetes-39 (a diabetes-specific quality of life measure) at one year. RESULTS: HbA(1c) levels improved for the overall cohort from baseline to one-year follow-up (t (74) = 3.09, p = .0029). One-year follow up HbA(1c) was correlated with worse overall quality of life (r = 0.33, p = 0.004). Improvements in HbA(1c) from baseline to one-year follow-up were associated with greater D-39 diabetes control (β = 0.23, p = .04) and D-39 sexual functioning (β = 0.25, p = .03) quality of life subscales. CONCLUSIONS: Improvements in HbA(1c) among participants completing a diabetes self-management program were associated with better diabetes-specific quality of life. Innovations in primary care that engage patients in self-management and improve clinical biomarkers, such as HbA(1c), may also be associated with better quality of life, a key outcome from the patient perspective.
format Online
Article
Text
id pubmed-3412738
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-34127382012-08-07 Hemoglobin A(1c) improvements and better diabetes-specific quality of life among participants completing diabetes self-management programs: A nested cohort study Khanna, Abhinav Bush, Amber L Swint, J Michael Peskin, Melissa Fleschler Street, Richard L Naik, Aanand D Health Qual Life Outcomes Research BACKGROUND: Numerous primary care innovations emphasize patient-centered processes of care. Within the context of these innovations, greater understanding is needed of the relationship between improvements in clinical endpoints and patient-centered outcomes. To address this gap, we evaluated the association between glycosylated hemoglobin (HbA(1c)) and diabetes-specific quality of life among patients completing diabetes self-management programs. METHODS: We conducted a retrospective cohort study nested within a randomized comparative effectiveness trial of diabetes self-management interventions in 75 diabetic patients. Multiple linear regression models were developed to examine the relationship between change in HbA(1c) from baseline to one-year follow-up and Diabetes-39 (a diabetes-specific quality of life measure) at one year. RESULTS: HbA(1c) levels improved for the overall cohort from baseline to one-year follow-up (t (74) = 3.09, p = .0029). One-year follow up HbA(1c) was correlated with worse overall quality of life (r = 0.33, p = 0.004). Improvements in HbA(1c) from baseline to one-year follow-up were associated with greater D-39 diabetes control (β = 0.23, p = .04) and D-39 sexual functioning (β = 0.25, p = .03) quality of life subscales. CONCLUSIONS: Improvements in HbA(1c) among participants completing a diabetes self-management program were associated with better diabetes-specific quality of life. Innovations in primary care that engage patients in self-management and improve clinical biomarkers, such as HbA(1c), may also be associated with better quality of life, a key outcome from the patient perspective. BioMed Central 2012-05-14 /pmc/articles/PMC3412738/ /pubmed/22583609 http://dx.doi.org/10.1186/1477-7525-10-48 Text en Copyright ©2012 Khanna et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Khanna, Abhinav
Bush, Amber L
Swint, J Michael
Peskin, Melissa Fleschler
Street, Richard L
Naik, Aanand D
Hemoglobin A(1c) improvements and better diabetes-specific quality of life among participants completing diabetes self-management programs: A nested cohort study
title Hemoglobin A(1c) improvements and better diabetes-specific quality of life among participants completing diabetes self-management programs: A nested cohort study
title_full Hemoglobin A(1c) improvements and better diabetes-specific quality of life among participants completing diabetes self-management programs: A nested cohort study
title_fullStr Hemoglobin A(1c) improvements and better diabetes-specific quality of life among participants completing diabetes self-management programs: A nested cohort study
title_full_unstemmed Hemoglobin A(1c) improvements and better diabetes-specific quality of life among participants completing diabetes self-management programs: A nested cohort study
title_short Hemoglobin A(1c) improvements and better diabetes-specific quality of life among participants completing diabetes self-management programs: A nested cohort study
title_sort hemoglobin a(1c) improvements and better diabetes-specific quality of life among participants completing diabetes self-management programs: a nested cohort study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412738/
https://www.ncbi.nlm.nih.gov/pubmed/22583609
http://dx.doi.org/10.1186/1477-7525-10-48
work_keys_str_mv AT khannaabhinav hemoglobina1cimprovementsandbetterdiabetesspecificqualityoflifeamongparticipantscompletingdiabetesselfmanagementprogramsanestedcohortstudy
AT bushamberl hemoglobina1cimprovementsandbetterdiabetesspecificqualityoflifeamongparticipantscompletingdiabetesselfmanagementprogramsanestedcohortstudy
AT swintjmichael hemoglobina1cimprovementsandbetterdiabetesspecificqualityoflifeamongparticipantscompletingdiabetesselfmanagementprogramsanestedcohortstudy
AT peskinmelissafleschler hemoglobina1cimprovementsandbetterdiabetesspecificqualityoflifeamongparticipantscompletingdiabetesselfmanagementprogramsanestedcohortstudy
AT streetrichardl hemoglobina1cimprovementsandbetterdiabetesspecificqualityoflifeamongparticipantscompletingdiabetesselfmanagementprogramsanestedcohortstudy
AT naikaanandd hemoglobina1cimprovementsandbetterdiabetesspecificqualityoflifeamongparticipantscompletingdiabetesselfmanagementprogramsanestedcohortstudy