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Sibutramine-induced mania as the first manifestation of bipolar disorder
BACKGROUND: Sibutramine, used in obesity treatment, has been associated with many neuropsychiatric side effects including hypomanic and manic episodes. Hypomanic/manic episodes related to sibutramine treatment were earlier reported in patients who had previous history of bipolar disorder, after sibu...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412751/ https://www.ncbi.nlm.nih.gov/pubmed/22607132 http://dx.doi.org/10.1186/1471-244X-12-43 |
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author | Waszkiewicz, Napoleon Zalewska-Szajda, Beata Szajda, Sławomir Dariusz Simonienko, Katarzyna Zalewska, Anna Szulc, Agata Ładny, Jerzy Robert Zwierz, Krzysztof |
author_facet | Waszkiewicz, Napoleon Zalewska-Szajda, Beata Szajda, Sławomir Dariusz Simonienko, Katarzyna Zalewska, Anna Szulc, Agata Ładny, Jerzy Robert Zwierz, Krzysztof |
author_sort | Waszkiewicz, Napoleon |
collection | PubMed |
description | BACKGROUND: Sibutramine, used in obesity treatment, has been associated with many neuropsychiatric side effects including hypomanic and manic episodes. Hypomanic/manic episodes related to sibutramine treatment were earlier reported in patients who had previous history of bipolar disorder, after sibutramine overdose, after over-the-counter product illegally containing very high dose of sibutramine, together with psychotic symptoms, in organic patient, or after interaction of sibutramine with other drugs. CASE PRESENTATION: We report the first case of a patient with clear manic episode, after treatment with recommended dose of sibutramine, without previous history of mood disorders, organic changes or drug interactions, that was followed by episode of depression. CONCLUSION: Minimal recommended dose of sibutramine induced manic episode that was the first manifestation of bipolar disorder. The manic episode, associated with sibutramine treatment, was induced in a person without previous history of mood disorders. Potential risks associated with the treatment of obesity using sibutramine warn physicians to be alert not only to common and cardiovascular but also to psychiatric adverse effects. A careful assessment of patient’s mental state and detailed psychiatric family history should be done before sibutramine treatment. In patients with a family history for bipolar disorder the use of even minimal dose of sibutramine should be contraindicated. |
format | Online Article Text |
id | pubmed-3412751 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-34127512012-08-07 Sibutramine-induced mania as the first manifestation of bipolar disorder Waszkiewicz, Napoleon Zalewska-Szajda, Beata Szajda, Sławomir Dariusz Simonienko, Katarzyna Zalewska, Anna Szulc, Agata Ładny, Jerzy Robert Zwierz, Krzysztof BMC Psychiatry Case Report BACKGROUND: Sibutramine, used in obesity treatment, has been associated with many neuropsychiatric side effects including hypomanic and manic episodes. Hypomanic/manic episodes related to sibutramine treatment were earlier reported in patients who had previous history of bipolar disorder, after sibutramine overdose, after over-the-counter product illegally containing very high dose of sibutramine, together with psychotic symptoms, in organic patient, or after interaction of sibutramine with other drugs. CASE PRESENTATION: We report the first case of a patient with clear manic episode, after treatment with recommended dose of sibutramine, without previous history of mood disorders, organic changes or drug interactions, that was followed by episode of depression. CONCLUSION: Minimal recommended dose of sibutramine induced manic episode that was the first manifestation of bipolar disorder. The manic episode, associated with sibutramine treatment, was induced in a person without previous history of mood disorders. Potential risks associated with the treatment of obesity using sibutramine warn physicians to be alert not only to common and cardiovascular but also to psychiatric adverse effects. A careful assessment of patient’s mental state and detailed psychiatric family history should be done before sibutramine treatment. In patients with a family history for bipolar disorder the use of even minimal dose of sibutramine should be contraindicated. BioMed Central 2012-05-18 /pmc/articles/PMC3412751/ /pubmed/22607132 http://dx.doi.org/10.1186/1471-244X-12-43 Text en Copyright ©2012 Waszkiewicz et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Waszkiewicz, Napoleon Zalewska-Szajda, Beata Szajda, Sławomir Dariusz Simonienko, Katarzyna Zalewska, Anna Szulc, Agata Ładny, Jerzy Robert Zwierz, Krzysztof Sibutramine-induced mania as the first manifestation of bipolar disorder |
title | Sibutramine-induced mania as the first manifestation of bipolar disorder |
title_full | Sibutramine-induced mania as the first manifestation of bipolar disorder |
title_fullStr | Sibutramine-induced mania as the first manifestation of bipolar disorder |
title_full_unstemmed | Sibutramine-induced mania as the first manifestation of bipolar disorder |
title_short | Sibutramine-induced mania as the first manifestation of bipolar disorder |
title_sort | sibutramine-induced mania as the first manifestation of bipolar disorder |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412751/ https://www.ncbi.nlm.nih.gov/pubmed/22607132 http://dx.doi.org/10.1186/1471-244X-12-43 |
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