Cargando…

Effects of HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG) on NEU/HER2 overexpressing mammary tumours in MMTV-NEU-NT mice monitored by Magnetic Resonance Spectroscopy

BACKGROUND: The importance of ERBB2/NEU/HER2 in the response of breast tumours to the heat shock protein 90 (HSP90) inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG; tanespimycin) has been demonstrated in the clinic. ERBB2 is an oncoprotein client that is highly dependent on HSP90. This and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rodrigues, Loreta M, Chung, Yuen-Li, Al Saffar, Nada M S, Sharp, Swee Y, Jackson, Laura E, Banerji, Udai, Stubbs, Marion, Leach, Martin O, Griffiths, John R, Workman, Paul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412754/ https://www.ncbi.nlm.nih.gov/pubmed/22621282 http://dx.doi.org/10.1186/1756-0500-5-250

Ejemplares similares

Effects of 17-allylamino-17-demethoxygeldanamycin (17-AAG) in transgenic mouse models of frontotemporal lobar degeneration and Alzheimer’s disease
por: Ho, Shuk Wai, et al.
Publicado: (2013)

Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin inhibits the proliferation of ARPE-19 cells
por: Yao, Jia-Qi, et al.
Publicado: (2010)

Hsp90 is expressed and represents a therapeutic target in human oesophageal cancer using the inhibitor 17-allylamino-17-demethoxygeldanamycin
por: Wu, X, et al.
Publicado: (2009)

Effects of 17-allylamino-17-demethoxygeldanamycin on the induction of apoptosis and cell cycle arrest in HCT-116 cells
por: Zhao, Xuerong, et al.
Publicado: (2017)

The Hsp90 inhibitor 17-(allylamino)-17-demethoxygeldanamycin increases cisplatin antitumor activity by inducing p53-mediated apoptosis in head and neck cancer
por: Roh, J-L, et al.
Publicado: (2013)

17-Allylamino-17-demethoxygeldanamycin induces downregulation of critical Hsp90 protein clients and results in cell cycle arrest and apoptosis of human urinary bladder cancer cells
por: Karkoulis, Panagiotis K, et al.
Publicado: (2010)

Synergistic effect of heat shock protein 90 inhibitor, 17-allylamino-17-demethoxygeldanamycin and X-rays, but not carbon-ion beams, on lethality in human oral squamous cell carcinoma cells
por: Musha, Atsushi, et al.
Publicado: (2012)

Addition of 17-(allylamino)-17-demethoxygeldanamycin to a suboptimal caspofungin treatment regimen in neutropenic rats with invasive pulmonary aspergillosis delays the time to death but does not enhance the overall therapeutic efficacy
por: Refos, Jeannine M., et al.
Publicado: (2017)

Population pharmacokinetic analysis of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) in adult patients with solid tumors
por: Aregbe, Abdulateef O., et al.
Publicado: (2012)

Radioprotective effects of oral 17-dimethylaminoethylamino-17-demethoxygeldanamycin in mice: bone marrow and small intestine
por: Lu, Xinyue, et al.
Publicado: (2013)

Widespread Non-Canonical Epigenetic Modifications in MMTV-NeuT Breast Cancer()()
por: Felts, Sara J., et al.
Publicado: (2015)

Mode of cell death induced by the HSP90 inhibitor 17-AAG (tanespimycin) is dependent on the expression of pro-apoptotic BAX
por: Powers, Marissa V, et al.
Publicado: (2013)

Mechanism of Inhibition of MMTV-neu and MMTV-wnt1 induced mammary oncogenesis by RARα agonist AM580
por: Lu, Yongke, et al.
Publicado: (2010)

Haploinsufficiency for p190B RhoGAP inhibits MMTV-Neu tumor progression
por: Heckman-Stoddard, Brandy M, et al.
Publicado: (2009)

MMTV-NeuT/ATTAC mice: a new model for studying the stromal tumor microenvironment
por: Yuan, Hongyan, et al.
Publicado: (2018)

Repercussion of Mitochondria Deformity Induced by Anti-Hsp90 Drug 17AAG in Human Tumor Cells
por: Vishal, Chaturvedi, et al.
Publicado: (2011)

Can RNAi-mediated hsp90α knockdown in combination with 17-AAG be a therapy for glioma?()
por: Mehta, Adi, et al.
Publicado: (2013)

Degradable Cross-Linked Nanoassemblies as Drug Carriers for Heat Shock Protein 90 Inhibitor 17-N-Allylamino-17-demethoxy-geldanamycin
por: Ponta, Andrei, et al.
Publicado: (2011)

Promotion of breast cancer by β-Hexachlorocyclohexane in MCF10AT1 cells and MMTV-neu mice
por: Wong, Patrick S, et al.
Publicado: (2007)

Correction: MMTV-NeuT/ATTAC mice: a new model for studying the stromal tumor microenvironment
por: Yuan, Hongyan, et al.
Publicado: (2018)

Molecular signature of response and potential pathways related to resistance to the HSP90 inhibitor, 17AAG, in breast cancer
por: Zajac, Magdalena, et al.
Publicado: (2010)

A Novel Mechanism of 17-AAG Therapeutic Efficacy on HSP90 Inhibition in MYCN-Amplified Neuroblastoma Cells
por: Hanna, Reine, et al.
Publicado: (2021)

HSP90 inhibitor 17AAG attenuates sevoflurane-induced neurotoxicity in rats and human neuroglioma cells via induction of HSP70
por: Liu, Min, et al.
Publicado: (2020)

17AAG Treatment Accelerates Doxorubicin Induced Cellular Senescence: Hsp90 Interferes with Enforced Senescence of Tumor Cells
por: Sarangi, Upasana, et al.
Publicado: (2012)

The Hsp90 inhibitor 17-AAG represses calcium-induced cytokeratin 1 and 10 expression in HaCaT keratinocytes
por: Miyoshi, Sadanori, et al.
Publicado: (2012)

Topically applied Hsp90 inhibitor 17AAG inhibits ultraviolet radiation-induced cutaneous squamous cell carcinomas
por: Singh, Anupama, et al.
Publicado: (2014)

Small molecule inhibitor screening identifified HSP90 inhibitor 17-AAG as potential therapeutic agent for gallbladder cancer
por: Weber, Helga, et al.
Publicado: (2017)

HSP90 Inhibitor 17-AAG Attenuates Nucleus Pulposus Inflammation and Catabolism Induced by M1-Polarized Macrophages
por: Zhang, Shuo, et al.
Publicado: (2022)

17AAG-induced internalisation of HER2-specific Affibody molecules
por: Göstring, Lovisa, et al.
Publicado: (2016)

Capsaicin binds the N-terminus of Hsp90, induces lysosomal degradation of Hsp70, and enhances the anti-tumor effects of 17-AAG (Tanespimycin)
por: Patwardhan, Chaitanya A., et al.
Publicado: (2023)

The Novel RXR Agonist MSU-42011 Differentially Regulates Gene Expression in Mammary Tumors of MMTV-Neu Mice
por: Reich, Lyndsey A., et al.
Publicado: (2023)

Blockade of Hsp90 by 17AAG antagonizes MDMX and synergizes with Nutlin to induce p53-mediated apoptosis in solid tumors
por: Vaseva, A V, et al.
Publicado: (2011)

NAD(P)H:Quinone Oxidoreductase-1 Expression Sensitizes Malignant Melanoma Cells to the HSP90 Inhibitor 17-AAG
por: Kasai, Shuya, et al.
Publicado: (2016)

17-AAG Induces Cytoplasmic α-Synuclein Aggregate Clearance by Induction of Autophagy
por: Riedel, Michael, et al.
Publicado: (2010)

Effects of salinomycin and 17-AAG on proliferation of human gastric cancer cells in vitro
por: Zhang, Zuwen, et al.
Publicado: (2017)

17-AAG-Induced Activation of the Autophagic Pathway in Leishmania Is Associated with Parasite Death
por: Petersen, Antonio Luis de O. A., et al.
Publicado: (2021)

Frequent overexpression of AMAP1, an Arf6 effector in cell invasion, is characteristic of the MMTV-PyMT rather than the MMTV-Neu human breast cancer model
por: Otsuka, Yutaro, et al.
Publicado: (2018)

P190B RhoGAP has pro-tumorigenic functions during MMTV-Neu mammary tumorigenesis and metastasis
por: McHenry, Peter R, et al.
Publicado: (2010)

Vaccination with pre-diagnostic tumor antigens but not established tumor antigens inhibits spontaneous tumorigenesis in TgMMTV-neu mice
por: Stanton, Sasha E, et al.
Publicado: (2013)

The combination of Hsp90 inhibitor 17AAG and heavy-ion irradiation provides effective tumor control in human lung cancer cells
por: Hirakawa, Hirokazu, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_k7t2sk2f5c6s2fpcfd058fqd1l