Selective Small Molecule Stat3 Inhibitor Reduces Breast Cancer Tumor-Initiating Cells and Improves Recurrence Free Survival in a Human-Xenograft Model

Metastasis and disease relapse are hypothesized to result from tumor initiating cells (TICs). Previously, we have defined a CD44+/CD24−/low mammosphere-forming tumorigenic 493-gene signature in breast cancer. Stat3 was identified as a critical node in self-renewal based on an ongoing lentiviral shRN...

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Detalles Bibliográficos
Autores principales: Dave, Bhuvanesh, Landis, Melissa D., Dobrolecki, Lacey E., Wu, Meng-Fen, Zhang, Xiaomei, Westbrook, Thomas F., Hilsenbeck, Susan G., Liu, Dan, Lewis, Michael T., Tweardy, David J., Chang, Jenny C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412855/
https://www.ncbi.nlm.nih.gov/pubmed/22879872
http://dx.doi.org/10.1371/journal.pone.0030207

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412855/
https://www.ncbi.nlm.nih.gov/pubmed/22879872
http://dx.doi.org/10.1371/journal.pone.0030207

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