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Markov Models of Use-Dependence and Reverse Use-Dependence during the Mouse Cardiac Action Potential
The fast component of the cardiac transient outward current, I(Ktof), is blocked by a number of drugs. The major molecular bases of I(Ktof) are Kv4.2/Kv4.3 voltage-gated potassium channels. Drugs with similar potencies but different blocking mechanisms have differing effects on action potential dura...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412869/ https://www.ncbi.nlm.nih.gov/pubmed/22879935 http://dx.doi.org/10.1371/journal.pone.0042295 |