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Clinical utility, safety, and tolerability of ezogabine (retigabine) in the treatment of epilepsy

One-third of patients with epilepsy continue to have seizures despite current treatments, indicating the need for better antiseizure medications with novel mechanisms of action. Ezogabine (retigabine) has recently been approved for adjunctive treatment of partial-onset seizures in adult patients wit...

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Detalles Bibliográficos
Autores principales: Ciliberto, Michael A, Weisenberg, Judith LZ, Wong, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413039/
https://www.ncbi.nlm.nih.gov/pubmed/22888276
http://dx.doi.org/10.2147/DHPS.S28814
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author Ciliberto, Michael A
Weisenberg, Judith LZ
Wong, Michael
author_facet Ciliberto, Michael A
Weisenberg, Judith LZ
Wong, Michael
author_sort Ciliberto, Michael A
collection PubMed
description One-third of patients with epilepsy continue to have seizures despite current treatments, indicating the need for better antiseizure medications with novel mechanisms of action. Ezogabine (retigabine) has recently been approved for adjunctive treatment of partial-onset seizures in adult patients with epilepsy. Ezogabine utilizes a novel mechanism of action, involving activation of specific potassium channels. The most common side effects of ezogabine are shared by most antiseizure medications and primarily consist of central nervous system (CNS) symptoms, such as somnolence, dizziness, confusion, and fatigue. In addition, a small percentage of patients on ezogabine experience a unique adverse effect affecting the bladder, which results in urinary hesitancy; thus, patients on ezogabine should be monitored carefully for potential urological symptoms. Overall, ezogabine appears to be well tolerated and represents a reasonable new option for treating patients with intractable epilepsy.
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spelling pubmed-34130392012-08-10 Clinical utility, safety, and tolerability of ezogabine (retigabine) in the treatment of epilepsy Ciliberto, Michael A Weisenberg, Judith LZ Wong, Michael Drug Healthc Patient Saf Review One-third of patients with epilepsy continue to have seizures despite current treatments, indicating the need for better antiseizure medications with novel mechanisms of action. Ezogabine (retigabine) has recently been approved for adjunctive treatment of partial-onset seizures in adult patients with epilepsy. Ezogabine utilizes a novel mechanism of action, involving activation of specific potassium channels. The most common side effects of ezogabine are shared by most antiseizure medications and primarily consist of central nervous system (CNS) symptoms, such as somnolence, dizziness, confusion, and fatigue. In addition, a small percentage of patients on ezogabine experience a unique adverse effect affecting the bladder, which results in urinary hesitancy; thus, patients on ezogabine should be monitored carefully for potential urological symptoms. Overall, ezogabine appears to be well tolerated and represents a reasonable new option for treating patients with intractable epilepsy. Dove Medical Press 2012-07-26 /pmc/articles/PMC3413039/ /pubmed/22888276 http://dx.doi.org/10.2147/DHPS.S28814 Text en © 2012 Ciliberto et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Review
Ciliberto, Michael A
Weisenberg, Judith LZ
Wong, Michael
Clinical utility, safety, and tolerability of ezogabine (retigabine) in the treatment of epilepsy
title Clinical utility, safety, and tolerability of ezogabine (retigabine) in the treatment of epilepsy
title_full Clinical utility, safety, and tolerability of ezogabine (retigabine) in the treatment of epilepsy
title_fullStr Clinical utility, safety, and tolerability of ezogabine (retigabine) in the treatment of epilepsy
title_full_unstemmed Clinical utility, safety, and tolerability of ezogabine (retigabine) in the treatment of epilepsy
title_short Clinical utility, safety, and tolerability of ezogabine (retigabine) in the treatment of epilepsy
title_sort clinical utility, safety, and tolerability of ezogabine (retigabine) in the treatment of epilepsy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413039/
https://www.ncbi.nlm.nih.gov/pubmed/22888276
http://dx.doi.org/10.2147/DHPS.S28814
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