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Efficiency of black cumin seeds on hematological factors in normal and hypercholesterolemic rabbits

BACKGROUND: Hypercholesterolemia is among the most common health problems treated with traditional remedies. Nigella sativa (NS) is an effective plant for treating hypercholesterolemia. However, the effects of this herb on hematologic factors and hemostasis system have not been elucidated. This stud...

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Autores principales: Asgary, Sedigheh, Najafi, Somayeh, Ghannadi, Alireza, Dashti, Gholamreza, Helalat, Alireza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413082/
https://www.ncbi.nlm.nih.gov/pubmed/23205047
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author Asgary, Sedigheh
Najafi, Somayeh
Ghannadi, Alireza
Dashti, Gholamreza
Helalat, Alireza
author_facet Asgary, Sedigheh
Najafi, Somayeh
Ghannadi, Alireza
Dashti, Gholamreza
Helalat, Alireza
author_sort Asgary, Sedigheh
collection PubMed
description BACKGROUND: Hypercholesterolemia is among the most common health problems treated with traditional remedies. Nigella sativa (NS) is an effective plant for treating hypercholesterolemia. However, the effects of this herb on hematologic factors and hemostasis system have not been elucidated. This study was designed to investigate the effects of NS on these factors in both normal and hypercholesterolemic rabbits. METHODS: In this research, twenty rabbits were randomly distributed into four groups of five. The groups received four different diets, namely normal, normal + NS (5%), hypercholesterolemic (1% cholesterol), and hypercholesterolemic (1% cholesterol) + NS (5%), for 8 weeks. After this period, WBC (white blood cell), RBC (red blood cell), HTC (hematocrit), HGB (hemoglobin content), PLT (platelet), fibrinogen (FIB) and factors VII (F VII) were measured. RESULTS: Using NS significantly increased PLT count in the normal group. In addition, it significantly decreased WBC counts in the hypercholesterolemic group (P < 0.05). However, dietary use of NS did not have any effects on other hematologic factors including RBC, HTC, HGB, FIB, and F VII (P < 0.05). CONCLUSION: Increased PLT numbers might cause enhanced coagulation. The achieved results call for more research on the effects of various diets (hypercholesterolemic and normal diet) supplemented with NS on different coagulation factors and hemostasis system.
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spelling pubmed-34130822012-12-01 Efficiency of black cumin seeds on hematological factors in normal and hypercholesterolemic rabbits Asgary, Sedigheh Najafi, Somayeh Ghannadi, Alireza Dashti, Gholamreza Helalat, Alireza ARYA Atheroscler Articles BACKGROUND: Hypercholesterolemia is among the most common health problems treated with traditional remedies. Nigella sativa (NS) is an effective plant for treating hypercholesterolemia. However, the effects of this herb on hematologic factors and hemostasis system have not been elucidated. This study was designed to investigate the effects of NS on these factors in both normal and hypercholesterolemic rabbits. METHODS: In this research, twenty rabbits were randomly distributed into four groups of five. The groups received four different diets, namely normal, normal + NS (5%), hypercholesterolemic (1% cholesterol), and hypercholesterolemic (1% cholesterol) + NS (5%), for 8 weeks. After this period, WBC (white blood cell), RBC (red blood cell), HTC (hematocrit), HGB (hemoglobin content), PLT (platelet), fibrinogen (FIB) and factors VII (F VII) were measured. RESULTS: Using NS significantly increased PLT count in the normal group. In addition, it significantly decreased WBC counts in the hypercholesterolemic group (P < 0.05). However, dietary use of NS did not have any effects on other hematologic factors including RBC, HTC, HGB, FIB, and F VII (P < 0.05). CONCLUSION: Increased PLT numbers might cause enhanced coagulation. The achieved results call for more research on the effects of various diets (hypercholesterolemic and normal diet) supplemented with NS on different coagulation factors and hemostasis system. Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences 2012 /pmc/articles/PMC3413082/ /pubmed/23205047 Text en © 2012 Isfahan Cardiovascular Research Center & Isfahan University of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
spellingShingle Articles
Asgary, Sedigheh
Najafi, Somayeh
Ghannadi, Alireza
Dashti, Gholamreza
Helalat, Alireza
Efficiency of black cumin seeds on hematological factors in normal and hypercholesterolemic rabbits
title Efficiency of black cumin seeds on hematological factors in normal and hypercholesterolemic rabbits
title_full Efficiency of black cumin seeds on hematological factors in normal and hypercholesterolemic rabbits
title_fullStr Efficiency of black cumin seeds on hematological factors in normal and hypercholesterolemic rabbits
title_full_unstemmed Efficiency of black cumin seeds on hematological factors in normal and hypercholesterolemic rabbits
title_short Efficiency of black cumin seeds on hematological factors in normal and hypercholesterolemic rabbits
title_sort efficiency of black cumin seeds on hematological factors in normal and hypercholesterolemic rabbits
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413082/
https://www.ncbi.nlm.nih.gov/pubmed/23205047
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