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Non-specific protein–DNA interactions control I-CreI target binding and cleavage

Homing endonucleases represent protein scaffolds that provide powerful tools for genome manipulation, as these enzymes possess a very low frequency of DNA cleavage in eukaryotic genomes due to their high specificity. The basis of protein–DNA recognition must be understood to generate tailored enzyme...

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Detalles Bibliográficos
Autores principales:	Molina, Rafael, Redondo, Pilar, Stella, Stefano, Marenchino, Marco, D’Abramo, Marco, Gervasio, Francesco Luigi, Charles Epinat, Jean, Valton, Julien, Grizot, Silvestre, Duchateau, Phillipe, Prieto, Jesús, Montoya, Guillermo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413129/ https://www.ncbi.nlm.nih.gov/pubmed/22495931 http://dx.doi.org/10.1093/nar/gks320

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