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Evidence that the Upf1-related molecular motor scans the 3′-UTR to ensure mRNA integrity

Upf1 is a highly conserved RNA helicase essential for nonsense-mediated mRNA decay (NMD), an mRNA quality-control mechanism that degrades aberrant mRNAs harboring premature termination codons (PTCs). For the activation of NMD, UPF1 interacts first with a translation–terminating ribosome and then wit...

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Detalles Bibliográficos
Autores principales:	Shigeoka, Toshiaki, Kato, Sayaka, Kawaichi, Masashi, Ishida, Yasumasa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	RNA
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413143/ https://www.ncbi.nlm.nih.gov/pubmed/22554850 http://dx.doi.org/10.1093/nar/gks344

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