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Hypertrophic scarring in cleft lip repair: a comparison of incidence among ethnic groups

BACKGROUND: Although hypertrophic scar (HTS) formation following cleft lip repair is relatively common, published rates vary widely, from 1% to nearly 50%. The risk factors associated with HTS formation in cleft patients are not well characterized. The primary aim of this retrospective study of 180...

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Autores principales: Soltani, Ali M, Francis, Cameron S, Motamed, Arash, Karatsonyi, Ashley L, Hammoudeh, Jeffrey A, Sanchez-Lara, Pedro A, Reinisch, John F, Urata, Mark M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413167/
https://www.ncbi.nlm.nih.gov/pubmed/22879780
http://dx.doi.org/10.2147/CLEP.S31119
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author Soltani, Ali M
Francis, Cameron S
Motamed, Arash
Karatsonyi, Ashley L
Hammoudeh, Jeffrey A
Sanchez-Lara, Pedro A
Reinisch, John F
Urata, Mark M
author_facet Soltani, Ali M
Francis, Cameron S
Motamed, Arash
Karatsonyi, Ashley L
Hammoudeh, Jeffrey A
Sanchez-Lara, Pedro A
Reinisch, John F
Urata, Mark M
author_sort Soltani, Ali M
collection PubMed
description BACKGROUND: Although hypertrophic scar (HTS) formation following cleft lip repair is relatively common, published rates vary widely, from 1% to nearly 50%. The risk factors associated with HTS formation in cleft patients are not well characterized. The primary aim of this retrospective study of 180 cleft lip repairs is to evaluate the frequency of postoperative HTS among various ethnic groups following cleft lip repair. METHODS: A retrospective chart view of patients undergoing primary cleft lip repair over a 16-year period (1990–2005) by the senior surgeon was performed. The primary outcome was the presence of HTS at 1 year postoperatively. Bivariate analysis and multivariable logistic regression were used to evaluate potential risk factors for HTS, including ethnicity, type and laterality of cleft, and gender. RESULTS: One hundred and eighty patients who underwent cleft lip repair were included in the study. The overall rate of postoperative HTS formation was 25%. Ethnicity alone was found to be an independent predictor of HTS formation. Caucasian patients had the lowest rate of HTS formation (11.8%) and were used as the reference group. HTS rates were significantly higher in the other ethnicities, 32.2% in Hispanic patients (odds ratio [OR]: 3.51; 95% confidence interval [CI]: 1.53–8.85), and 36.3% for Asian patients (OR 4.27; 95% CI: 1.36–13.70). Sex, cleft type, and cleft laterality were not associated with increased rates of HTS. CONCLUSIONS: Differences in ethnic makeup of respective patient populations may be a major factor influencing the wide variability of reported HTS rates. Consideration should be given to potential prophylactic treatments for HTS in susceptible ethnic populations.
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spelling pubmed-34131672012-08-09 Hypertrophic scarring in cleft lip repair: a comparison of incidence among ethnic groups Soltani, Ali M Francis, Cameron S Motamed, Arash Karatsonyi, Ashley L Hammoudeh, Jeffrey A Sanchez-Lara, Pedro A Reinisch, John F Urata, Mark M Clin Epidemiol Original Research BACKGROUND: Although hypertrophic scar (HTS) formation following cleft lip repair is relatively common, published rates vary widely, from 1% to nearly 50%. The risk factors associated with HTS formation in cleft patients are not well characterized. The primary aim of this retrospective study of 180 cleft lip repairs is to evaluate the frequency of postoperative HTS among various ethnic groups following cleft lip repair. METHODS: A retrospective chart view of patients undergoing primary cleft lip repair over a 16-year period (1990–2005) by the senior surgeon was performed. The primary outcome was the presence of HTS at 1 year postoperatively. Bivariate analysis and multivariable logistic regression were used to evaluate potential risk factors for HTS, including ethnicity, type and laterality of cleft, and gender. RESULTS: One hundred and eighty patients who underwent cleft lip repair were included in the study. The overall rate of postoperative HTS formation was 25%. Ethnicity alone was found to be an independent predictor of HTS formation. Caucasian patients had the lowest rate of HTS formation (11.8%) and were used as the reference group. HTS rates were significantly higher in the other ethnicities, 32.2% in Hispanic patients (odds ratio [OR]: 3.51; 95% confidence interval [CI]: 1.53–8.85), and 36.3% for Asian patients (OR 4.27; 95% CI: 1.36–13.70). Sex, cleft type, and cleft laterality were not associated with increased rates of HTS. CONCLUSIONS: Differences in ethnic makeup of respective patient populations may be a major factor influencing the wide variability of reported HTS rates. Consideration should be given to potential prophylactic treatments for HTS in susceptible ethnic populations. Dove Medical Press 2012-07-26 /pmc/articles/PMC3413167/ /pubmed/22879780 http://dx.doi.org/10.2147/CLEP.S31119 Text en © 2012 Soltani et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Original Research
Soltani, Ali M
Francis, Cameron S
Motamed, Arash
Karatsonyi, Ashley L
Hammoudeh, Jeffrey A
Sanchez-Lara, Pedro A
Reinisch, John F
Urata, Mark M
Hypertrophic scarring in cleft lip repair: a comparison of incidence among ethnic groups
title Hypertrophic scarring in cleft lip repair: a comparison of incidence among ethnic groups
title_full Hypertrophic scarring in cleft lip repair: a comparison of incidence among ethnic groups
title_fullStr Hypertrophic scarring in cleft lip repair: a comparison of incidence among ethnic groups
title_full_unstemmed Hypertrophic scarring in cleft lip repair: a comparison of incidence among ethnic groups
title_short Hypertrophic scarring in cleft lip repair: a comparison of incidence among ethnic groups
title_sort hypertrophic scarring in cleft lip repair: a comparison of incidence among ethnic groups
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413167/
https://www.ncbi.nlm.nih.gov/pubmed/22879780
http://dx.doi.org/10.2147/CLEP.S31119
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