Cargando…

Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice

Ataxia telangiectasia (A-T) mutated (ATM) kinase orchestrates deoxyribonucleic acid (DNA) damage responses by phosphorylating numerous substrates implicated in DNA repair and cell cycle checkpoint activation. A-T patients and mouse models that express no ATM protein undergo normal embryonic developm...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yamamoto, Kenta, Wang, Yunyue, Jiang, Wenxia, Liu, Xiangyu, Dubois, Richard L., Lin, Chyuan-Sheng, Ludwig, Thomas, Bakkenist, Christopher J., Zha, Shan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2012
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413350/ https://www.ncbi.nlm.nih.gov/pubmed/22869596 http://dx.doi.org/10.1083/jcb.201204098

Ejemplares similares

Kinase-dead ATM protein is highly oncogenic and can be preferentially targeted by Topo-isomerase I inhibitors
por: Yamamoto, Kenta, et al.
Publicado: (2016)

Loss of ATM kinase activity leads to embryonic lethality in mice
por: Daniel, Jeremy A., et al.
Publicado: (2012)

Kinase-dead ATR differs from ATR loss by limiting the dynamic exchange of ATR and RPA
por: Menolfi, Demis, et al.
Publicado: (2018)

ATM Kinase Dead: From Ataxia Telangiectasia Syndrome to Cancer
por: Putti, Sabrina, et al.
Publicado: (2021)

The Telomeric Protein TRF2 Binds the ATM Kinase and Can Inhibit the ATM-Dependent DNA Damage Response
por: Karlseder, Jan, et al.
Publicado: (2004)

Inhibition of ATM kinase rescues planarian regeneration after lethal radiation
por: Shiroor, Divya A, et al.
Publicado: (2023)

Loss of p53 Ser18 and Atm Results in Embryonic Lethality without Cooperation in Tumorigenesis
por: Armata, Heather L., et al.
Publicado: (2011)

ATM and MET kinases are synthetic lethal with non-genotoxic activation of p53
por: Sullivan, Kelly D., et al.
Publicado: (2012)

A kinase-dead knock-in mutation in mTOR leads to early embryonic lethality and is dispensable for the immune system in heterozygous mice
por: Shor, Boris, et al.
Publicado: (2009)

ATM, ATR and DNA-PKcs kinases—the lessons from the mouse models: inhibition ≠ deletion
por: Menolfi, Demis, et al.
Publicado: (2020)

ATM in prevention of genomic instability
por: Masai, Hisao
Publicado: (2014)

Functional analyses of ATM, ATR and Fanconi anemia proteins in lung carcinoma: ATM, ATR and FA in lung carcinoma
por: Beumer, Jan H., et al.
Publicado: (2015)

Loss of PICH Results in Chromosomal Instability, p53 Activation, and Embryonic Lethality
por: Albers, Eliene, et al.
Publicado: (2018)

Haploinsufficiency of Bcl11b suppresses the progression of ATM-deficient T cell lymphomas
por: Pinkney, Kerice A., et al.
Publicado: (2015)

Neonatal Lethality in Knockout Mice Expressing the Kinase-Dead Form of the Gefitinib Target GAK Is Caused by Pulmonary Dysfunction
por: Tabara, Hiroe, et al.
Publicado: (2011)

A synthetic lethality screen reveals ING5 as a genetic dependency of catalytically dead Set1A/COMPASS in mouse embryonic stem cells
por: Cenik, Bercin K., et al.
Publicado: (2022)

ATM: Functions of ATM Kinase and Its Relevance to Hereditary Tumors
por: Ueno, Sayaka, et al.
Publicado: (2022)

Targeted disruption of Rab10 causes early embryonic lethality
por: Lv, Pingping, et al.
Publicado: (2015)

Nuclear myosin/actin-motored contact between homologous chromosomes is initiated by ATM kinase and homology-directed repair proteins at double-strand DNA breaks to suppress chromosome rearrangements
por: Evdokimova, Viktoria N., et al.
Publicado: (2018)

ATR kinase supports normal proliferation in the early S phase by preventing replication resource exhaustion
por: Menolfi, Demis, et al.
Publicado: (2023)

The orally active and bioavailable ATR kinase inhibitor AZD6738 potentiates the anti-tumor effects of cisplatin to resolve ATM-deficient non-small cell lung cancer in vivo
por: Vendetti, Frank P., et al.
Publicado: (2015)

Structure of the human dimeric ATM kinase
por: Lau, Wilson C. Y., et al.
Publicado: (2016)

Mobile phone signal exposure triggers a hormesis-like effect in Atm(+/+) and Atm(−/−) mouse embryonic fibroblasts
por: Sun, Chuan, et al.
Publicado: (2016)

Autotaxin Overexpression Causes Embryonic Lethality and Vascular Defects
por: Yukiura, Hiroshi, et al.
Publicado: (2015)

Germline ATM Mutations Detected by Somatic DNA Sequencing in Lethal Prostate Cancer
por: Grochot, Rafael, et al.
Publicado: (2023)

53BP1 loss rescues embryonic lethality but not genomic instability of BRCA1 total knockout mice
por: Chen, Jiyuan, et al.
Publicado: (2020)

Depletion of Nesprin-2 is associated with an embryonic lethal phenotype in mice
por: Mroß, Carmen, et al.
Publicado: (2018)

Deficiency of the Stress Kinase P38α Results in Embryonic Lethality: Characterization of the Kinase Dependence of Stress Responses of Enzyme-Deficient Embryonic Stem Cells
por: Allen, Melanie, et al.
Publicado: (2000)

ATM protein is deficient in over 40% of lung adenocarcinomas
por: Villaruz, Liza C., et al.
Publicado: (2016)

Mutation at Intronic Repeats of the Ataxia-Telangiectasia Mutated (ATM) Gene and ATM Protein Loss in Primary Gastric Cancer with Microsatellite Instability
por: Kim, Hee Sung, et al.
Publicado: (2013)

A pharmacological screen for compounds that rescue the developmental lethality of a Drosophila ATM mutant
por: Rimkus, Stacey A., et al.
Publicado: (2018)

The Combination of ATM and Chk1 Inhibitors Induces Synthetic Lethality in Colorectal Cancer Cells
por: Tozaki, Yuri, et al.
Publicado: (2023)

Structure of the intact ATM/Tel1 kinase
por: Wang, Xuejuan, et al.
Publicado: (2016)

The epigenetic modifier HDAC2 and the checkpoint kinase ATM determine the responses of microsatellite instable colorectal cancer cells to 5-fluorouracil
por: Kiweler, Nicole, et al.
Publicado: (2022)

Embryonic lethality is not sufficient to explain hourglass-like conservation of vertebrate embryos
por: Uchida, Yui, et al.
Publicado: (2018)

Pharmacologic ATM but not ATR kinase inhibition abrogates p21-dependent G1 arrest and promotes gastrointestinal syndrome after total body irradiation
por: Vendetti, Frank P., et al.
Publicado: (2017)

ATM Damage Response and XLF Repair Factor are Functionally Redundant In Joining DNA Breaks
por: Zha, Shan, et al.
Publicado: (2010)

Combined inhibition of EZH2 and ATM is synthetic lethal in BRCA1-deficient breast cancer
por: Ratz, Leonie, et al.
Publicado: (2022)

Synthetic lethal interactions of DEAD/H-box helicases as targets for cancer therapy
por: Arna, Ananna Bhadra, et al.
Publicado: (2023)

TLE6 mutation causes the earliest known human embryonic lethality
por: Alazami, Anas M., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_e4bpjs3u9li939vs35n1pqvo9t