A first line of defense against ER stress

BiP is the predominant DnaK/Hsp70-type chaperone protein in the ER. It is required for folding and assembling newly synthesized ER client proteins, yet having too much BiP inhibits folding. In this issue, Chambers et al. (2012. J. Cell Biol. doi:10.1083/jcb.201202005) report that ADP ribosylation of...

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Detalles Bibliográficos
Autores principales: Pincus, David, Walter, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413362/
https://www.ncbi.nlm.nih.gov/pubmed/22869593
http://dx.doi.org/10.1083/jcb.201207076
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author Pincus, David
Walter, Peter
author_facet Pincus, David
Walter, Peter
author_sort Pincus, David
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description BiP is the predominant DnaK/Hsp70-type chaperone protein in the ER. It is required for folding and assembling newly synthesized ER client proteins, yet having too much BiP inhibits folding. In this issue, Chambers et al. (2012. J. Cell Biol. doi:10.1083/jcb.201202005) report that ADP ribosylation of BiP provides a reversible switch that fine tunes BiP activity according to need.
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spelling pubmed-34133622013-02-06 A first line of defense against ER stress Pincus, David Walter, Peter J Cell Biol Reviews BiP is the predominant DnaK/Hsp70-type chaperone protein in the ER. It is required for folding and assembling newly synthesized ER client proteins, yet having too much BiP inhibits folding. In this issue, Chambers et al. (2012. J. Cell Biol. doi:10.1083/jcb.201202005) report that ADP ribosylation of BiP provides a reversible switch that fine tunes BiP activity according to need. The Rockefeller University Press 2012-08-06 /pmc/articles/PMC3413362/ /pubmed/22869593 http://dx.doi.org/10.1083/jcb.201207076 Text en © 2012 Pincus and Walter This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Reviews
Pincus, David
Walter, Peter
A first line of defense against ER stress
title A first line of defense against ER stress
title_full A first line of defense against ER stress
title_fullStr A first line of defense against ER stress
title_full_unstemmed A first line of defense against ER stress
title_short A first line of defense against ER stress
title_sort first line of defense against er stress
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413362/
https://www.ncbi.nlm.nih.gov/pubmed/22869593
http://dx.doi.org/10.1083/jcb.201207076
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