The ATM protein: The importance of being active

The ataxia telangiectasia mutated (ATM) protein kinase regulates the cellular response to deoxyribonucleic acid (DNA) double-strand breaks by phosphorylating numerous players in the extensive DNA damage response network. Two papers in this issue (Daniel et al. 2012. J. Cell Biol. http://dx.doi.org/1...

Descripción completa

Detalles Bibliográficos
Autores principales: Shiloh, Yosef, Ziv, Yael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413363/
https://www.ncbi.nlm.nih.gov/pubmed/22869592
http://dx.doi.org/10.1083/jcb.201207063
_version_ 1782240050124161024
author Shiloh, Yosef
Ziv, Yael
author_facet Shiloh, Yosef
Ziv, Yael
author_sort Shiloh, Yosef
collection PubMed
description The ataxia telangiectasia mutated (ATM) protein kinase regulates the cellular response to deoxyribonucleic acid (DNA) double-strand breaks by phosphorylating numerous players in the extensive DNA damage response network. Two papers in this issue (Daniel et al. 2012. J. Cell Biol. http://dx.doi.org/10.1083/jcb201204035; Yamamoto et al. 2012. J. Cell Biol. http://dx.doi.org/10.1083/jcb201204098) strikingly show that, in mice, the presence of a catalytically inactive version of ATM is embryonically lethal. This is surprising because mice completely lacking ATM have a much more moderate phenotype. The findings impact on basic cancer research and cancer therapeutics.
format Online
Article
Text
id pubmed-3413363
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-34133632013-02-06 The ATM protein: The importance of being active Shiloh, Yosef Ziv, Yael J Cell Biol Reviews The ataxia telangiectasia mutated (ATM) protein kinase regulates the cellular response to deoxyribonucleic acid (DNA) double-strand breaks by phosphorylating numerous players in the extensive DNA damage response network. Two papers in this issue (Daniel et al. 2012. J. Cell Biol. http://dx.doi.org/10.1083/jcb201204035; Yamamoto et al. 2012. J. Cell Biol. http://dx.doi.org/10.1083/jcb201204098) strikingly show that, in mice, the presence of a catalytically inactive version of ATM is embryonically lethal. This is surprising because mice completely lacking ATM have a much more moderate phenotype. The findings impact on basic cancer research and cancer therapeutics. The Rockefeller University Press 2012-08-06 /pmc/articles/PMC3413363/ /pubmed/22869592 http://dx.doi.org/10.1083/jcb.201207063 Text en © 2012 Shiloh and Ziv This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Reviews
Shiloh, Yosef
Ziv, Yael
The ATM protein: The importance of being active
title The ATM protein: The importance of being active
title_full The ATM protein: The importance of being active
title_fullStr The ATM protein: The importance of being active
title_full_unstemmed The ATM protein: The importance of being active
title_short The ATM protein: The importance of being active
title_sort atm protein: the importance of being active
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413363/
https://www.ncbi.nlm.nih.gov/pubmed/22869592
http://dx.doi.org/10.1083/jcb.201207063
work_keys_str_mv AT shilohyosef theatmproteintheimportanceofbeingactive
AT zivyael theatmproteintheimportanceofbeingactive
AT shilohyosef atmproteintheimportanceofbeingactive
AT zivyael atmproteintheimportanceofbeingactive

Ejemplares similares