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ADP ribosylation adapts an ER chaperone response to short-term fluctuations in unfolded protein load
Gene expression programs that regulate the abundance of the chaperone BiP adapt the endoplasmic reticulum (ER) to unfolded protein load. However, such programs are slow compared with physiological fluctuations in secreted protein synthesis. While searching for mechanisms that fill this temporal gap...
Autores principales: | Chambers, Joseph E., Petrova, Kseniya, Tomba, Giulia, Vendruscolo, Michele, Ron, David |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413365/ https://www.ncbi.nlm.nih.gov/pubmed/22869598 http://dx.doi.org/10.1083/jcb.201202005 |
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