Cargando…

Complement factor H and interleukin gene polymorphisms in patients with non-infectious intermediate and posterior uveitis

OBJECTIVE: To investigate the associations of complement factor H (CFH), KIAA1109, and interleukin-27 (IL-27) gene polymorphisms in patients with non-infectious intermediate and posterior uveitis. METHODS: The study cohort consisted of a total of 95 Chinese non-infectious uveitis patients, including...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Ming-ming, Lai, Timothy Y.Y., Tam, Pancy O.S., Chiang, Sylvia W.Y., Chan, Carmen K.M., Luk, Fiona O.J., Ng, Tsz-Kin, Pang, Chi-Pui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Vision 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413425/
https://www.ncbi.nlm.nih.gov/pubmed/22876110
_version_ 1782240059609579520
author Yang, Ming-ming
Lai, Timothy Y.Y.
Tam, Pancy O.S.
Chiang, Sylvia W.Y.
Chan, Carmen K.M.
Luk, Fiona O.J.
Ng, Tsz-Kin
Pang, Chi-Pui
author_facet Yang, Ming-ming
Lai, Timothy Y.Y.
Tam, Pancy O.S.
Chiang, Sylvia W.Y.
Chan, Carmen K.M.
Luk, Fiona O.J.
Ng, Tsz-Kin
Pang, Chi-Pui
author_sort Yang, Ming-ming
collection PubMed
description OBJECTIVE: To investigate the associations of complement factor H (CFH), KIAA1109, and interleukin-27 (IL-27) gene polymorphisms in patients with non-infectious intermediate and posterior uveitis. METHODS: The study cohort consisted of a total of 95 Chinese non-infectious uveitis patients, including 38 patients with intermediate uveitis (IU), 38 patients with Vogt–Koyanagi–Harada disease (VKH), and 19 patients with Behçet’s disease and 308 healthy controls. The genotypes of CFH-rs800292, KIAA1109-rs4505848, and IL27-rs4788084 were determined using TaqMan single nucleotide polymorphism genotyping assays. RESULTS: The frequency of carriers of G allele for CFH-rs800292 was significantly higher in patients with non-infectious intermediate and posterior uveitis than in controls (GG/AG versus AA; p=0.02). No significant association was found between uveitis and both KIAA1109-rs4505848 and IL27-rs4788084. In stratified analysis by gender, the frequency of carriers with G allele for KIAA1109-rs4505848 was significantly higher in male uveitis patients than in male controls (GG/AG versus AA; p=0.034). There was no significant difference in allelic and genotypic frequencies for CFH-rs800292 and IL27-rs4788084 in either male or female groups. In addition, higher frequency of KIAA1109-rs4505848 G allele was found in Behçet’s disease patients compared with controls and IU patients (p=0.01 and p=0.003, respectively). CONCLUSIONS: Our results demonstrated that CFH-rs800292 and KIAA1109-rs4505848 are associated with non-infectious intermediate and posterior uveitis. Moreover, gender susceptibility for uveitis might be involved in the KIAA1109 gene and the KIAA1109-rs4505848 polymorphism might be associated with the development of Behçet’s disease.
format Online
Article
Text
id pubmed-3413425
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Molecular Vision
record_format MEDLINE/PubMed
spelling pubmed-34134252012-08-08 Complement factor H and interleukin gene polymorphisms in patients with non-infectious intermediate and posterior uveitis Yang, Ming-ming Lai, Timothy Y.Y. Tam, Pancy O.S. Chiang, Sylvia W.Y. Chan, Carmen K.M. Luk, Fiona O.J. Ng, Tsz-Kin Pang, Chi-Pui Mol Vis Research Article OBJECTIVE: To investigate the associations of complement factor H (CFH), KIAA1109, and interleukin-27 (IL-27) gene polymorphisms in patients with non-infectious intermediate and posterior uveitis. METHODS: The study cohort consisted of a total of 95 Chinese non-infectious uveitis patients, including 38 patients with intermediate uveitis (IU), 38 patients with Vogt–Koyanagi–Harada disease (VKH), and 19 patients with Behçet’s disease and 308 healthy controls. The genotypes of CFH-rs800292, KIAA1109-rs4505848, and IL27-rs4788084 were determined using TaqMan single nucleotide polymorphism genotyping assays. RESULTS: The frequency of carriers of G allele for CFH-rs800292 was significantly higher in patients with non-infectious intermediate and posterior uveitis than in controls (GG/AG versus AA; p=0.02). No significant association was found between uveitis and both KIAA1109-rs4505848 and IL27-rs4788084. In stratified analysis by gender, the frequency of carriers with G allele for KIAA1109-rs4505848 was significantly higher in male uveitis patients than in male controls (GG/AG versus AA; p=0.034). There was no significant difference in allelic and genotypic frequencies for CFH-rs800292 and IL27-rs4788084 in either male or female groups. In addition, higher frequency of KIAA1109-rs4505848 G allele was found in Behçet’s disease patients compared with controls and IU patients (p=0.01 and p=0.003, respectively). CONCLUSIONS: Our results demonstrated that CFH-rs800292 and KIAA1109-rs4505848 are associated with non-infectious intermediate and posterior uveitis. Moreover, gender susceptibility for uveitis might be involved in the KIAA1109 gene and the KIAA1109-rs4505848 polymorphism might be associated with the development of Behçet’s disease. Molecular Vision 2012-07-11 /pmc/articles/PMC3413425/ /pubmed/22876110 Text en Copyright © 2012 Molecular Vision. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Yang, Ming-ming
Lai, Timothy Y.Y.
Tam, Pancy O.S.
Chiang, Sylvia W.Y.
Chan, Carmen K.M.
Luk, Fiona O.J.
Ng, Tsz-Kin
Pang, Chi-Pui
Complement factor H and interleukin gene polymorphisms in patients with non-infectious intermediate and posterior uveitis
title Complement factor H and interleukin gene polymorphisms in patients with non-infectious intermediate and posterior uveitis
title_full Complement factor H and interleukin gene polymorphisms in patients with non-infectious intermediate and posterior uveitis
title_fullStr Complement factor H and interleukin gene polymorphisms in patients with non-infectious intermediate and posterior uveitis
title_full_unstemmed Complement factor H and interleukin gene polymorphisms in patients with non-infectious intermediate and posterior uveitis
title_short Complement factor H and interleukin gene polymorphisms in patients with non-infectious intermediate and posterior uveitis
title_sort complement factor h and interleukin gene polymorphisms in patients with non-infectious intermediate and posterior uveitis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413425/
https://www.ncbi.nlm.nih.gov/pubmed/22876110
work_keys_str_mv AT yangmingming complementfactorhandinterleukingenepolymorphismsinpatientswithnoninfectiousintermediateandposterioruveitis
AT laitimothyyy complementfactorhandinterleukingenepolymorphismsinpatientswithnoninfectiousintermediateandposterioruveitis
AT tampancyos complementfactorhandinterleukingenepolymorphismsinpatientswithnoninfectiousintermediateandposterioruveitis
AT chiangsylviawy complementfactorhandinterleukingenepolymorphismsinpatientswithnoninfectiousintermediateandposterioruveitis
AT chancarmenkm complementfactorhandinterleukingenepolymorphismsinpatientswithnoninfectiousintermediateandposterioruveitis
AT lukfionaoj complementfactorhandinterleukingenepolymorphismsinpatientswithnoninfectiousintermediateandposterioruveitis
AT ngtszkin complementfactorhandinterleukingenepolymorphismsinpatientswithnoninfectiousintermediateandposterioruveitis
AT pangchipui complementfactorhandinterleukingenepolymorphismsinpatientswithnoninfectiousintermediateandposterioruveitis