Mouse p53-Deficient Cancer Models as Platforms for Obtaining Genomic Predictors of Human Cancer Clinical Outcomes

Mutations in the TP53 gene are very common in human cancers, and are associated with poor clinical outcome. Transgenic mouse models lacking the Trp53 gene or that express mutant Trp53 transgenes produce tumours with malignant features in many organs. We previously showed the transcriptome of a p53-d...

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Detalles Bibliográficos
Autores principales: Dueñas, Marta, Santos, Mirentxu, Aranda, Juan F., Bielza, Concha, Martínez-Cruz, Ana B., Lorz, Corina, Taron, Miquel, Ciruelos, Eva M., Rodríguez-Peralto, José L., Martín, Miguel, Larrañaga, Pedro, Dahabreh, Jubrail, Stathopoulos, George P., Rosell, Rafael, Paramio, Jesús M., García-Escudero, Ramón
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413665/
https://www.ncbi.nlm.nih.gov/pubmed/22880004
http://dx.doi.org/10.1371/journal.pone.0042494

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