Quantitative Model of Cell Cycle Arrest and Cellular Senescence in Primary Human Fibroblasts

Primary human fibroblasts in tissue culture undergo a limited number of cell divisions before entering a non-replicative “senescent” state. At early population doublings (PD), fibroblasts are proliferation-competent displaying exponential growth. During further cell passaging, an increasing number o...

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Detalles Bibliográficos
Autores principales: Schäuble, Sascha, Klement, Karolin, Marthandan, Shiva, Münch, Sandra, Heiland, Ines, Schuster, Stefan, Hemmerich, Peter, Diekmann, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413708/
https://www.ncbi.nlm.nih.gov/pubmed/22879912
http://dx.doi.org/10.1371/journal.pone.0042150

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413708/
https://www.ncbi.nlm.nih.gov/pubmed/22879912
http://dx.doi.org/10.1371/journal.pone.0042150

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