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Translational actomyosin research: fundamental insights and applications hand in hand

This review describes the development towards actomyosin based nanodevices taking a starting point in pioneering studies in the 1990s based on conventional in vitro motility assays. References are given to parallel developments using the kinesin–microtubule motor system. The early developments focus...

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Autor principal: Månsson, Alf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413815/
https://www.ncbi.nlm.nih.gov/pubmed/22638606
http://dx.doi.org/10.1007/s10974-012-9298-5
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author Månsson, Alf
author_facet Månsson, Alf
author_sort Månsson, Alf
collection PubMed
description This review describes the development towards actomyosin based nanodevices taking a starting point in pioneering studies in the 1990s based on conventional in vitro motility assays. References are given to parallel developments using the kinesin–microtubule motor system. The early developments focused on achieving cargo-transportation using actin filaments as cargo-loaded shuttles propelled by surface-adsorbed heavy meromyosin along micro- and nanofabricated channels. These efforts prompted extensive studies of surface–motor interactions contributing with new insights of general relevance in surface and colloid chemistry. As a result of these early efforts, a range of complex devices have now emerged, spanning applications in medical diagnostics, biocomputation and formation of complex nanostructures by self-organization. In addition to giving a comprehensive account of the developments towards real-world applications an important goal of the present review is to demonstrate important connections between the applied studies and fundamental biophysical studies of actomyosin and muscle function. Thus the manipulation of the motor proteins towards applications has resulted in new insights into methodological aspects of the in vitro motiliy assay. Other developments have advanced the understanding of the dynamic materials properties of actin filaments.
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spelling pubmed-34138152012-08-23 Translational actomyosin research: fundamental insights and applications hand in hand Månsson, Alf J Muscle Res Cell Motil EMC2012 Special Issue - Review This review describes the development towards actomyosin based nanodevices taking a starting point in pioneering studies in the 1990s based on conventional in vitro motility assays. References are given to parallel developments using the kinesin–microtubule motor system. The early developments focused on achieving cargo-transportation using actin filaments as cargo-loaded shuttles propelled by surface-adsorbed heavy meromyosin along micro- and nanofabricated channels. These efforts prompted extensive studies of surface–motor interactions contributing with new insights of general relevance in surface and colloid chemistry. As a result of these early efforts, a range of complex devices have now emerged, spanning applications in medical diagnostics, biocomputation and formation of complex nanostructures by self-organization. In addition to giving a comprehensive account of the developments towards real-world applications an important goal of the present review is to demonstrate important connections between the applied studies and fundamental biophysical studies of actomyosin and muscle function. Thus the manipulation of the motor proteins towards applications has resulted in new insights into methodological aspects of the in vitro motiliy assay. Other developments have advanced the understanding of the dynamic materials properties of actin filaments. Springer Netherlands 2012-05-26 2012 /pmc/articles/PMC3413815/ /pubmed/22638606 http://dx.doi.org/10.1007/s10974-012-9298-5 Text en © The Author(s) 2012 https://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle EMC2012 Special Issue - Review
Månsson, Alf
Translational actomyosin research: fundamental insights and applications hand in hand
title Translational actomyosin research: fundamental insights and applications hand in hand
title_full Translational actomyosin research: fundamental insights and applications hand in hand
title_fullStr Translational actomyosin research: fundamental insights and applications hand in hand
title_full_unstemmed Translational actomyosin research: fundamental insights and applications hand in hand
title_short Translational actomyosin research: fundamental insights and applications hand in hand
title_sort translational actomyosin research: fundamental insights and applications hand in hand
topic EMC2012 Special Issue - Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413815/
https://www.ncbi.nlm.nih.gov/pubmed/22638606
http://dx.doi.org/10.1007/s10974-012-9298-5
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