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Expression of the BRCA1 complex member BRE predicts disease free survival in breast cancer

Breast cancer is one of the leading causes of cancer mortality in women. Recent advances in gene expression profiling have indicated that breast cancer is a heterogeneous disease and the current prognostication using clinico-pathological features is not sufficient to fully predict therapy response a...

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Autores principales: Noordermeer, Sylvie M., Wennemers, Marloes, Bergevoet, Saskia M., van der Heijden, Adrian, Tönnissen, Evelyn, Sweep, Fred C. G. J., Jansen, Joop H., Span, Paul N., van der Reijden, Bert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413819/
https://www.ncbi.nlm.nih.gov/pubmed/22706632
http://dx.doi.org/10.1007/s10549-012-2122-5
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author Noordermeer, Sylvie M.
Wennemers, Marloes
Bergevoet, Saskia M.
van der Heijden, Adrian
Tönnissen, Evelyn
Sweep, Fred C. G. J.
Jansen, Joop H.
Span, Paul N.
van der Reijden, Bert A.
author_facet Noordermeer, Sylvie M.
Wennemers, Marloes
Bergevoet, Saskia M.
van der Heijden, Adrian
Tönnissen, Evelyn
Sweep, Fred C. G. J.
Jansen, Joop H.
Span, Paul N.
van der Reijden, Bert A.
author_sort Noordermeer, Sylvie M.
collection PubMed
description Breast cancer is one of the leading causes of cancer mortality in women. Recent advances in gene expression profiling have indicated that breast cancer is a heterogeneous disease and the current prognostication using clinico-pathological features is not sufficient to fully predict therapy response and disease outcome. In this retrospective study, we show that expression levels of BRE, which encodes a member of the BRCA1 DNA damage repair complex, predicted disease-free survival (DFS) in non-familial breast cancer patients. The predictive value of BRE expression depended on whether patients received radiotherapy as a part of their primary treatment. In radiotherapy-treated patients, high BRE expression predicted a favorable DFS (hazard ratio (HR) = 0.47, 95 % confidence interval (CI) = 0.28–0.78, p = 0.004), while in non-treated patients, high BRE expression predicted an adverse prognosis (HR = 2.59, 95 % CI = 1.00–6.75, p = 0.05). Among radiotherapy-treated patients, the prognostic impact of BRE expression was confined to patients with smaller tumors (HR = 0.23, 95 % CI = 0.068–0.75, p = 0.015) and it remained an independent factor after correction for the other prognostic factors age, tumor size, lymph node involvement, and histological grade (HR = 0.50, CI = 0.27–0.90, p = 0.021). In addition, high BRE expression predicted a favorable relapse-free survival in a publicly available dataset of 2,324 breast cancer patients (HR = 0.59, CI = 0.51–0.68, p < 0.001). These data indicate that BRE is an interesting candidate for future functional studies aimed at developing targeted therapies.
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spelling pubmed-34138192012-08-23 Expression of the BRCA1 complex member BRE predicts disease free survival in breast cancer Noordermeer, Sylvie M. Wennemers, Marloes Bergevoet, Saskia M. van der Heijden, Adrian Tönnissen, Evelyn Sweep, Fred C. G. J. Jansen, Joop H. Span, Paul N. van der Reijden, Bert A. Breast Cancer Res Treat Preclinical Study Breast cancer is one of the leading causes of cancer mortality in women. Recent advances in gene expression profiling have indicated that breast cancer is a heterogeneous disease and the current prognostication using clinico-pathological features is not sufficient to fully predict therapy response and disease outcome. In this retrospective study, we show that expression levels of BRE, which encodes a member of the BRCA1 DNA damage repair complex, predicted disease-free survival (DFS) in non-familial breast cancer patients. The predictive value of BRE expression depended on whether patients received radiotherapy as a part of their primary treatment. In radiotherapy-treated patients, high BRE expression predicted a favorable DFS (hazard ratio (HR) = 0.47, 95 % confidence interval (CI) = 0.28–0.78, p = 0.004), while in non-treated patients, high BRE expression predicted an adverse prognosis (HR = 2.59, 95 % CI = 1.00–6.75, p = 0.05). Among radiotherapy-treated patients, the prognostic impact of BRE expression was confined to patients with smaller tumors (HR = 0.23, 95 % CI = 0.068–0.75, p = 0.015) and it remained an independent factor after correction for the other prognostic factors age, tumor size, lymph node involvement, and histological grade (HR = 0.50, CI = 0.27–0.90, p = 0.021). In addition, high BRE expression predicted a favorable relapse-free survival in a publicly available dataset of 2,324 breast cancer patients (HR = 0.59, CI = 0.51–0.68, p < 0.001). These data indicate that BRE is an interesting candidate for future functional studies aimed at developing targeted therapies. Springer US 2012-06-16 2012 /pmc/articles/PMC3413819/ /pubmed/22706632 http://dx.doi.org/10.1007/s10549-012-2122-5 Text en © The Author(s) 2012 https://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Preclinical Study
Noordermeer, Sylvie M.
Wennemers, Marloes
Bergevoet, Saskia M.
van der Heijden, Adrian
Tönnissen, Evelyn
Sweep, Fred C. G. J.
Jansen, Joop H.
Span, Paul N.
van der Reijden, Bert A.
Expression of the BRCA1 complex member BRE predicts disease free survival in breast cancer
title Expression of the BRCA1 complex member BRE predicts disease free survival in breast cancer
title_full Expression of the BRCA1 complex member BRE predicts disease free survival in breast cancer
title_fullStr Expression of the BRCA1 complex member BRE predicts disease free survival in breast cancer
title_full_unstemmed Expression of the BRCA1 complex member BRE predicts disease free survival in breast cancer
title_short Expression of the BRCA1 complex member BRE predicts disease free survival in breast cancer
title_sort expression of the brca1 complex member bre predicts disease free survival in breast cancer
topic Preclinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413819/
https://www.ncbi.nlm.nih.gov/pubmed/22706632
http://dx.doi.org/10.1007/s10549-012-2122-5
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