Towards multivalent CD1d ligands: synthesis and biological activity of homodimeric α-galactosyl ceramide analogues

A library of dimeric CD1d ligands, containing two α-galactosyl ceramide (α-GalCer) units linked by spacers of varying lengths has been synthesised. The key dimerisation reactions were carried out via copper-catalysed click reactions between a 6″-azido-6″-deoxy-α-galactosyl ceramide derivative and va...

Descripción completa

Detalles Bibliográficos
Autores principales: Jervis, Peter J., Moulis, Marie, Jukes, John-Paul, Ghadbane, Hemza, Cox, Liam R., Cerundolo, Vincenzo, Besra, Gurdyal S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413882/
https://www.ncbi.nlm.nih.gov/pubmed/22445102
http://dx.doi.org/10.1016/j.carres.2012.02.034
_version_ 1782240118226026496
author Jervis, Peter J.
Moulis, Marie
Jukes, John-Paul
Ghadbane, Hemza
Cox, Liam R.
Cerundolo, Vincenzo
Besra, Gurdyal S.
author_facet Jervis, Peter J.
Moulis, Marie
Jukes, John-Paul
Ghadbane, Hemza
Cox, Liam R.
Cerundolo, Vincenzo
Besra, Gurdyal S.
author_sort Jervis, Peter J.
collection PubMed
description A library of dimeric CD1d ligands, containing two α-galactosyl ceramide (α-GalCer) units linked by spacers of varying lengths has been synthesised. The key dimerisation reactions were carried out via copper-catalysed click reactions between a 6″-azido-6″-deoxy-α-galactosyl ceramide derivative and various diynes. Each α-GalCer dimer was tested for its ability to stimulate iNKT cells.
format Online
Article
Text
id pubmed-3413882
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-34138822012-08-20 Towards multivalent CD1d ligands: synthesis and biological activity of homodimeric α-galactosyl ceramide analogues Jervis, Peter J. Moulis, Marie Jukes, John-Paul Ghadbane, Hemza Cox, Liam R. Cerundolo, Vincenzo Besra, Gurdyal S. Carbohydr Res Article A library of dimeric CD1d ligands, containing two α-galactosyl ceramide (α-GalCer) units linked by spacers of varying lengths has been synthesised. The key dimerisation reactions were carried out via copper-catalysed click reactions between a 6″-azido-6″-deoxy-α-galactosyl ceramide derivative and various diynes. Each α-GalCer dimer was tested for its ability to stimulate iNKT cells. Elsevier 2012-07-15 /pmc/articles/PMC3413882/ /pubmed/22445102 http://dx.doi.org/10.1016/j.carres.2012.02.034 Text en © 2012 Elsevier Ltd. https://creativecommons.org/licenses/by/3.0/Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license
spellingShingle Article
Jervis, Peter J.
Moulis, Marie
Jukes, John-Paul
Ghadbane, Hemza
Cox, Liam R.
Cerundolo, Vincenzo
Besra, Gurdyal S.
Towards multivalent CD1d ligands: synthesis and biological activity of homodimeric α-galactosyl ceramide analogues
title Towards multivalent CD1d ligands: synthesis and biological activity of homodimeric α-galactosyl ceramide analogues
title_full Towards multivalent CD1d ligands: synthesis and biological activity of homodimeric α-galactosyl ceramide analogues
title_fullStr Towards multivalent CD1d ligands: synthesis and biological activity of homodimeric α-galactosyl ceramide analogues
title_full_unstemmed Towards multivalent CD1d ligands: synthesis and biological activity of homodimeric α-galactosyl ceramide analogues
title_short Towards multivalent CD1d ligands: synthesis and biological activity of homodimeric α-galactosyl ceramide analogues
title_sort towards multivalent cd1d ligands: synthesis and biological activity of homodimeric α-galactosyl ceramide analogues
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413882/
https://www.ncbi.nlm.nih.gov/pubmed/22445102
http://dx.doi.org/10.1016/j.carres.2012.02.034
work_keys_str_mv AT jervispeterj towardsmultivalentcd1dligandssynthesisandbiologicalactivityofhomodimericagalactosylceramideanalogues
AT moulismarie towardsmultivalentcd1dligandssynthesisandbiologicalactivityofhomodimericagalactosylceramideanalogues
AT jukesjohnpaul towardsmultivalentcd1dligandssynthesisandbiologicalactivityofhomodimericagalactosylceramideanalogues
AT ghadbanehemza towardsmultivalentcd1dligandssynthesisandbiologicalactivityofhomodimericagalactosylceramideanalogues
AT coxliamr towardsmultivalentcd1dligandssynthesisandbiologicalactivityofhomodimericagalactosylceramideanalogues
AT cerundolovincenzo towardsmultivalentcd1dligandssynthesisandbiologicalactivityofhomodimericagalactosylceramideanalogues
AT besragurdyals towardsmultivalentcd1dligandssynthesisandbiologicalactivityofhomodimericagalactosylceramideanalogues

Ejemplares similares