Hematopoietic Stem Cell Development, Niches, and Signaling Pathways

Hematopoietic stem cells (HSCs) play a key role in hematopoietic system that functions mainly in homeostasis and immune response. HSCs transplantation has been applied for the treatment of several diseases. However, HSCs persist in the small quantity within the body, mostly in the quiescent state. U...

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Detalles Bibliográficos
Autores principales: Chotinantakul, Kamonnaree, Leeanansaksiri, Wilairat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413998/
https://www.ncbi.nlm.nih.gov/pubmed/22900188
http://dx.doi.org/10.1155/2012/270425
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author Chotinantakul, Kamonnaree
Leeanansaksiri, Wilairat
author_facet Chotinantakul, Kamonnaree
Leeanansaksiri, Wilairat
author_sort Chotinantakul, Kamonnaree
collection PubMed
description Hematopoietic stem cells (HSCs) play a key role in hematopoietic system that functions mainly in homeostasis and immune response. HSCs transplantation has been applied for the treatment of several diseases. However, HSCs persist in the small quantity within the body, mostly in the quiescent state. Understanding the basic knowledge of HSCs is useful for stem cell biology research and therapeutic medicine development. Thus, this paper emphasizes on HSC origin, source, development, the niche, and signaling pathways which support HSC maintenance and balance between self-renewal and proliferation which will be useful for the advancement of HSC expansion and transplantation in the future.
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spelling pubmed-34139982012-08-16 Hematopoietic Stem Cell Development, Niches, and Signaling Pathways Chotinantakul, Kamonnaree Leeanansaksiri, Wilairat Bone Marrow Res Review Article Hematopoietic stem cells (HSCs) play a key role in hematopoietic system that functions mainly in homeostasis and immune response. HSCs transplantation has been applied for the treatment of several diseases. However, HSCs persist in the small quantity within the body, mostly in the quiescent state. Understanding the basic knowledge of HSCs is useful for stem cell biology research and therapeutic medicine development. Thus, this paper emphasizes on HSC origin, source, development, the niche, and signaling pathways which support HSC maintenance and balance between self-renewal and proliferation which will be useful for the advancement of HSC expansion and transplantation in the future. Hindawi Publishing Corporation 2012 2012-07-30 /pmc/articles/PMC3413998/ /pubmed/22900188 http://dx.doi.org/10.1155/2012/270425 Text en Copyright © 2012 K. Chotinantakul and W. Leeanansaksiri. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Chotinantakul, Kamonnaree
Leeanansaksiri, Wilairat
Hematopoietic Stem Cell Development, Niches, and Signaling Pathways
title Hematopoietic Stem Cell Development, Niches, and Signaling Pathways
title_full Hematopoietic Stem Cell Development, Niches, and Signaling Pathways
title_fullStr Hematopoietic Stem Cell Development, Niches, and Signaling Pathways
title_full_unstemmed Hematopoietic Stem Cell Development, Niches, and Signaling Pathways
title_short Hematopoietic Stem Cell Development, Niches, and Signaling Pathways
title_sort hematopoietic stem cell development, niches, and signaling pathways
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413998/
https://www.ncbi.nlm.nih.gov/pubmed/22900188
http://dx.doi.org/10.1155/2012/270425
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