Capsular Switching in Invasive Neisseria meningitidis, Brazil

During the 1990s, an epidemic of B:4 Neisseria meningitidis infections affected Brazil. Subsequent increase in C:4 disease suggested B→C capsular switching. This study identified B→C switches within the sequence type 32 complex. Substantial disease related to capsular switching emphasizes the need f...

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Detalles Bibliográficos
Autores principales: Castiñeiras, Terezinha M. P. P., Barroso, David E., Marsh, Jane W., Tulenko, Mary M., Krauland, Mary G., Rebelo, Maria C., Harrison, Lee H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2012
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414017/
https://www.ncbi.nlm.nih.gov/pubmed/22840713
http://dx.doi.org/10.3201/eid1808.111344
Descripción
Sumario:During the 1990s, an epidemic of B:4 Neisseria meningitidis infections affected Brazil. Subsequent increase in C:4 disease suggested B→C capsular switching. This study identified B→C switches within the sequence type 32 complex. Substantial disease related to capsular switching emphasizes the need for surveillance of circulating meningococcal strains to optimize disease control.

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