Cargando…

Anorectal Dysfunction in Multiple Sclerosis: A Systematic Review

Constipation and fecal incontinence are common in patients with neuromuscular diseases. Despite their high prevalence and potential impact on overall quality of life, few studies have addressed anorectal dysfunction in patients with multiple sclerosis (MS). The goal of this paper is to define the pr...

Descripción completa

Detalles Bibliográficos
Autores principales: Nusrat, Sanober, Gulick, Elsie, Levinthal, David, Bielefeldt, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scholarly Research Network 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414061/
https://www.ncbi.nlm.nih.gov/pubmed/22900202
http://dx.doi.org/10.5402/2012/376023
_version_ 1782240144537944064
author Nusrat, Sanober
Gulick, Elsie
Levinthal, David
Bielefeldt, Klaus
author_facet Nusrat, Sanober
Gulick, Elsie
Levinthal, David
Bielefeldt, Klaus
author_sort Nusrat, Sanober
collection PubMed
description Constipation and fecal incontinence are common in patients with neuromuscular diseases. Despite their high prevalence and potential impact on overall quality of life, few studies have addressed anorectal dysfunction in patients with multiple sclerosis (MS). The goal of this paper is to define the prevalence, pathophysiology, impact, and potential treatment of constipation and incontinence in MS patients. Methods. The PubMed database was searched for English language publications between January 1973 and December 2011. Articles were reviewed to assess the definition of the study population, duration, type and severity of MS, sex distribution, prevalence, impact, results of physiologic testing, and treatments. Results. The reported prevalence of constipation and fecal incontinence ranged around 40%. Anorectal dysfunction significantly affected patients with nearly 1 in 6 patients limiting social activities or even quitting work due to symptoms. Caregivers listed toileting as a common and significant burden. The only randomized controlled trial showed a marginal improvement of constipation with abdominal massage. All other reports lacked control interventions and only demonstrated improvement in individuals with milder symptoms. Conclusion. Anorectal dysfunction is a common manifestation in MS that significantly affects quality of life. Therapies are at best moderately effective and often cumbersome, highlighting the need for simple and more helpful interventions.
format Online
Article
Text
id pubmed-3414061
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher International Scholarly Research Network
record_format MEDLINE/PubMed
spelling pubmed-34140612012-08-16 Anorectal Dysfunction in Multiple Sclerosis: A Systematic Review Nusrat, Sanober Gulick, Elsie Levinthal, David Bielefeldt, Klaus ISRN Neurol Review Article Constipation and fecal incontinence are common in patients with neuromuscular diseases. Despite their high prevalence and potential impact on overall quality of life, few studies have addressed anorectal dysfunction in patients with multiple sclerosis (MS). The goal of this paper is to define the prevalence, pathophysiology, impact, and potential treatment of constipation and incontinence in MS patients. Methods. The PubMed database was searched for English language publications between January 1973 and December 2011. Articles were reviewed to assess the definition of the study population, duration, type and severity of MS, sex distribution, prevalence, impact, results of physiologic testing, and treatments. Results. The reported prevalence of constipation and fecal incontinence ranged around 40%. Anorectal dysfunction significantly affected patients with nearly 1 in 6 patients limiting social activities or even quitting work due to symptoms. Caregivers listed toileting as a common and significant burden. The only randomized controlled trial showed a marginal improvement of constipation with abdominal massage. All other reports lacked control interventions and only demonstrated improvement in individuals with milder symptoms. Conclusion. Anorectal dysfunction is a common manifestation in MS that significantly affects quality of life. Therapies are at best moderately effective and often cumbersome, highlighting the need for simple and more helpful interventions. International Scholarly Research Network 2012-07-29 /pmc/articles/PMC3414061/ /pubmed/22900202 http://dx.doi.org/10.5402/2012/376023 Text en Copyright © 2012 Sanober Nusrat et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Nusrat, Sanober
Gulick, Elsie
Levinthal, David
Bielefeldt, Klaus
Anorectal Dysfunction in Multiple Sclerosis: A Systematic Review
title Anorectal Dysfunction in Multiple Sclerosis: A Systematic Review
title_full Anorectal Dysfunction in Multiple Sclerosis: A Systematic Review
title_fullStr Anorectal Dysfunction in Multiple Sclerosis: A Systematic Review
title_full_unstemmed Anorectal Dysfunction in Multiple Sclerosis: A Systematic Review
title_short Anorectal Dysfunction in Multiple Sclerosis: A Systematic Review
title_sort anorectal dysfunction in multiple sclerosis: a systematic review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414061/
https://www.ncbi.nlm.nih.gov/pubmed/22900202
http://dx.doi.org/10.5402/2012/376023
work_keys_str_mv AT nusratsanober anorectaldysfunctioninmultiplesclerosisasystematicreview
AT gulickelsie anorectaldysfunctioninmultiplesclerosisasystematicreview
AT levinthaldavid anorectaldysfunctioninmultiplesclerosisasystematicreview
AT bielefeldtklaus anorectaldysfunctioninmultiplesclerosisasystematicreview