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Anorectal Dysfunction in Multiple Sclerosis: A Systematic Review
Constipation and fecal incontinence are common in patients with neuromuscular diseases. Despite their high prevalence and potential impact on overall quality of life, few studies have addressed anorectal dysfunction in patients with multiple sclerosis (MS). The goal of this paper is to define the pr...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scholarly Research Network
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414061/ https://www.ncbi.nlm.nih.gov/pubmed/22900202 http://dx.doi.org/10.5402/2012/376023 |
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author | Nusrat, Sanober Gulick, Elsie Levinthal, David Bielefeldt, Klaus |
author_facet | Nusrat, Sanober Gulick, Elsie Levinthal, David Bielefeldt, Klaus |
author_sort | Nusrat, Sanober |
collection | PubMed |
description | Constipation and fecal incontinence are common in patients with neuromuscular diseases. Despite their high prevalence and potential impact on overall quality of life, few studies have addressed anorectal dysfunction in patients with multiple sclerosis (MS). The goal of this paper is to define the prevalence, pathophysiology, impact, and potential treatment of constipation and incontinence in MS patients. Methods. The PubMed database was searched for English language publications between January 1973 and December 2011. Articles were reviewed to assess the definition of the study population, duration, type and severity of MS, sex distribution, prevalence, impact, results of physiologic testing, and treatments. Results. The reported prevalence of constipation and fecal incontinence ranged around 40%. Anorectal dysfunction significantly affected patients with nearly 1 in 6 patients limiting social activities or even quitting work due to symptoms. Caregivers listed toileting as a common and significant burden. The only randomized controlled trial showed a marginal improvement of constipation with abdominal massage. All other reports lacked control interventions and only demonstrated improvement in individuals with milder symptoms. Conclusion. Anorectal dysfunction is a common manifestation in MS that significantly affects quality of life. Therapies are at best moderately effective and often cumbersome, highlighting the need for simple and more helpful interventions. |
format | Online Article Text |
id | pubmed-3414061 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | International Scholarly Research Network |
record_format | MEDLINE/PubMed |
spelling | pubmed-34140612012-08-16 Anorectal Dysfunction in Multiple Sclerosis: A Systematic Review Nusrat, Sanober Gulick, Elsie Levinthal, David Bielefeldt, Klaus ISRN Neurol Review Article Constipation and fecal incontinence are common in patients with neuromuscular diseases. Despite their high prevalence and potential impact on overall quality of life, few studies have addressed anorectal dysfunction in patients with multiple sclerosis (MS). The goal of this paper is to define the prevalence, pathophysiology, impact, and potential treatment of constipation and incontinence in MS patients. Methods. The PubMed database was searched for English language publications between January 1973 and December 2011. Articles were reviewed to assess the definition of the study population, duration, type and severity of MS, sex distribution, prevalence, impact, results of physiologic testing, and treatments. Results. The reported prevalence of constipation and fecal incontinence ranged around 40%. Anorectal dysfunction significantly affected patients with nearly 1 in 6 patients limiting social activities or even quitting work due to symptoms. Caregivers listed toileting as a common and significant burden. The only randomized controlled trial showed a marginal improvement of constipation with abdominal massage. All other reports lacked control interventions and only demonstrated improvement in individuals with milder symptoms. Conclusion. Anorectal dysfunction is a common manifestation in MS that significantly affects quality of life. Therapies are at best moderately effective and often cumbersome, highlighting the need for simple and more helpful interventions. International Scholarly Research Network 2012-07-29 /pmc/articles/PMC3414061/ /pubmed/22900202 http://dx.doi.org/10.5402/2012/376023 Text en Copyright © 2012 Sanober Nusrat et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Nusrat, Sanober Gulick, Elsie Levinthal, David Bielefeldt, Klaus Anorectal Dysfunction in Multiple Sclerosis: A Systematic Review |
title | Anorectal Dysfunction in Multiple Sclerosis: A Systematic Review |
title_full | Anorectal Dysfunction in Multiple Sclerosis: A Systematic Review |
title_fullStr | Anorectal Dysfunction in Multiple Sclerosis: A Systematic Review |
title_full_unstemmed | Anorectal Dysfunction in Multiple Sclerosis: A Systematic Review |
title_short | Anorectal Dysfunction in Multiple Sclerosis: A Systematic Review |
title_sort | anorectal dysfunction in multiple sclerosis: a systematic review |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414061/ https://www.ncbi.nlm.nih.gov/pubmed/22900202 http://dx.doi.org/10.5402/2012/376023 |
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