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Stability of membranous nanostructures: a possible key mechanism in cancer progression
Membranous nanostructures, such as nanovesicles and nanotubules, are an important pool of biological membranes. Recent results indicate that they constitute cell-cell communication systems and that cancer development is influenced by these systems. Nanovesicles that are pinched off from cancer cells...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414204/ https://www.ncbi.nlm.nih.gov/pubmed/22888223 http://dx.doi.org/10.2147/IJN.S29076 |
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author | Kralj-Iglic, Veronika |
author_facet | Kralj-Iglic, Veronika |
author_sort | Kralj-Iglic, Veronika |
collection | PubMed |
description | Membranous nanostructures, such as nanovesicles and nanotubules, are an important pool of biological membranes. Recent results indicate that they constitute cell-cell communication systems and that cancer development is influenced by these systems. Nanovesicles that are pinched off from cancer cells can move within the circulation and interact with distant cells. It has been suggested and indicated by experimental evidence that nanovesicles can induce metastases from the primary tumor in this way. Therefore, it is of importance to understand better the mechanisms of membrane budding and vesiculation. Here, a theoretical description is presented concerning consistently related lateral membrane composition, orientational ordering of membrane constituents, and a stable shape of nanovesicles and nanotubules. It is shown that the character of stable nanostructures reflects the composition of the membrane and the intrinsic shape of its constituents. An extension of the fluid mosaic model of biological membranes is suggested by taking into account curvature-mediated orientational ordering of the membrane constituents on strongly anisotropically curved regions. Based on experimental data for artificial membranes, a possible antimetastatic effect of plasma constituents via mediation of attractive interaction between membranous structures is suggested. This mediated attractive interaction hypothetically suppresses nanovesiculation by causing adhesion of buds to the mother membrane and preventing them from being pinched off from the membrane. |
format | Online Article Text |
id | pubmed-3414204 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-34142042012-08-10 Stability of membranous nanostructures: a possible key mechanism in cancer progression Kralj-Iglic, Veronika Int J Nanomedicine Review Membranous nanostructures, such as nanovesicles and nanotubules, are an important pool of biological membranes. Recent results indicate that they constitute cell-cell communication systems and that cancer development is influenced by these systems. Nanovesicles that are pinched off from cancer cells can move within the circulation and interact with distant cells. It has been suggested and indicated by experimental evidence that nanovesicles can induce metastases from the primary tumor in this way. Therefore, it is of importance to understand better the mechanisms of membrane budding and vesiculation. Here, a theoretical description is presented concerning consistently related lateral membrane composition, orientational ordering of membrane constituents, and a stable shape of nanovesicles and nanotubules. It is shown that the character of stable nanostructures reflects the composition of the membrane and the intrinsic shape of its constituents. An extension of the fluid mosaic model of biological membranes is suggested by taking into account curvature-mediated orientational ordering of the membrane constituents on strongly anisotropically curved regions. Based on experimental data for artificial membranes, a possible antimetastatic effect of plasma constituents via mediation of attractive interaction between membranous structures is suggested. This mediated attractive interaction hypothetically suppresses nanovesiculation by causing adhesion of buds to the mother membrane and preventing them from being pinched off from the membrane. Dove Medical Press 2012 2012-07-12 /pmc/articles/PMC3414204/ /pubmed/22888223 http://dx.doi.org/10.2147/IJN.S29076 Text en © 2012 Kralj-Iglic, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. |
spellingShingle | Review Kralj-Iglic, Veronika Stability of membranous nanostructures: a possible key mechanism in cancer progression |
title | Stability of membranous nanostructures: a possible key mechanism in cancer progression |
title_full | Stability of membranous nanostructures: a possible key mechanism in cancer progression |
title_fullStr | Stability of membranous nanostructures: a possible key mechanism in cancer progression |
title_full_unstemmed | Stability of membranous nanostructures: a possible key mechanism in cancer progression |
title_short | Stability of membranous nanostructures: a possible key mechanism in cancer progression |
title_sort | stability of membranous nanostructures: a possible key mechanism in cancer progression |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414204/ https://www.ncbi.nlm.nih.gov/pubmed/22888223 http://dx.doi.org/10.2147/IJN.S29076 |
work_keys_str_mv | AT kraljiglicveronika stabilityofmembranousnanostructuresapossiblekeymechanismincancerprogression |