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Stability of membranous nanostructures: a possible key mechanism in cancer progression

Membranous nanostructures, such as nanovesicles and nanotubules, are an important pool of biological membranes. Recent results indicate that they constitute cell-cell communication systems and that cancer development is influenced by these systems. Nanovesicles that are pinched off from cancer cells...

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Autor principal: Kralj-Iglic, Veronika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414204/
https://www.ncbi.nlm.nih.gov/pubmed/22888223
http://dx.doi.org/10.2147/IJN.S29076
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author Kralj-Iglic, Veronika
author_facet Kralj-Iglic, Veronika
author_sort Kralj-Iglic, Veronika
collection PubMed
description Membranous nanostructures, such as nanovesicles and nanotubules, are an important pool of biological membranes. Recent results indicate that they constitute cell-cell communication systems and that cancer development is influenced by these systems. Nanovesicles that are pinched off from cancer cells can move within the circulation and interact with distant cells. It has been suggested and indicated by experimental evidence that nanovesicles can induce metastases from the primary tumor in this way. Therefore, it is of importance to understand better the mechanisms of membrane budding and vesiculation. Here, a theoretical description is presented concerning consistently related lateral membrane composition, orientational ordering of membrane constituents, and a stable shape of nanovesicles and nanotubules. It is shown that the character of stable nanostructures reflects the composition of the membrane and the intrinsic shape of its constituents. An extension of the fluid mosaic model of biological membranes is suggested by taking into account curvature-mediated orientational ordering of the membrane constituents on strongly anisotropically curved regions. Based on experimental data for artificial membranes, a possible antimetastatic effect of plasma constituents via mediation of attractive interaction between membranous structures is suggested. This mediated attractive interaction hypothetically suppresses nanovesiculation by causing adhesion of buds to the mother membrane and preventing them from being pinched off from the membrane.
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spelling pubmed-34142042012-08-10 Stability of membranous nanostructures: a possible key mechanism in cancer progression Kralj-Iglic, Veronika Int J Nanomedicine Review Membranous nanostructures, such as nanovesicles and nanotubules, are an important pool of biological membranes. Recent results indicate that they constitute cell-cell communication systems and that cancer development is influenced by these systems. Nanovesicles that are pinched off from cancer cells can move within the circulation and interact with distant cells. It has been suggested and indicated by experimental evidence that nanovesicles can induce metastases from the primary tumor in this way. Therefore, it is of importance to understand better the mechanisms of membrane budding and vesiculation. Here, a theoretical description is presented concerning consistently related lateral membrane composition, orientational ordering of membrane constituents, and a stable shape of nanovesicles and nanotubules. It is shown that the character of stable nanostructures reflects the composition of the membrane and the intrinsic shape of its constituents. An extension of the fluid mosaic model of biological membranes is suggested by taking into account curvature-mediated orientational ordering of the membrane constituents on strongly anisotropically curved regions. Based on experimental data for artificial membranes, a possible antimetastatic effect of plasma constituents via mediation of attractive interaction between membranous structures is suggested. This mediated attractive interaction hypothetically suppresses nanovesiculation by causing adhesion of buds to the mother membrane and preventing them from being pinched off from the membrane. Dove Medical Press 2012 2012-07-12 /pmc/articles/PMC3414204/ /pubmed/22888223 http://dx.doi.org/10.2147/IJN.S29076 Text en © 2012 Kralj-Iglic, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Review
Kralj-Iglic, Veronika
Stability of membranous nanostructures: a possible key mechanism in cancer progression
title Stability of membranous nanostructures: a possible key mechanism in cancer progression
title_full Stability of membranous nanostructures: a possible key mechanism in cancer progression
title_fullStr Stability of membranous nanostructures: a possible key mechanism in cancer progression
title_full_unstemmed Stability of membranous nanostructures: a possible key mechanism in cancer progression
title_short Stability of membranous nanostructures: a possible key mechanism in cancer progression
title_sort stability of membranous nanostructures: a possible key mechanism in cancer progression
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414204/
https://www.ncbi.nlm.nih.gov/pubmed/22888223
http://dx.doi.org/10.2147/IJN.S29076
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