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Synthetic polyspermine imidazole-4, 5-amide as an efficient and cytotoxicity-free gene delivery system
A chemically dynamic spermine-based polymer: polyspermine imidazole-4, 5-amide (PSIA, Mw > 7 kDa) was designed, synthesized, and evaluated in terms of its ability to deliver nucleic acids. This polymer was made from an endogenous monomer professionally condensing genes in sperms, spermine, and a...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414223/ https://www.ncbi.nlm.nih.gov/pubmed/22888236 http://dx.doi.org/10.2147/IJN.S33101 |