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Synthetic polyspermine imidazole-4, 5-amide as an efficient and cytotoxicity-free gene delivery system

A chemically dynamic spermine-based polymer: polyspermine imidazole-4, 5-amide (PSIA, Mw > 7 kDa) was designed, synthesized, and evaluated in terms of its ability to deliver nucleic acids. This polymer was made from an endogenous monomer professionally condensing genes in sperms, spermine, and a...

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Detalles Bibliográficos
Autores principales:	Duan, Shi-Yue, Ge, Xue-Mei, Lu, Nan, Wu, Fei, Yuan, Weien, Jin, Tuo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2012
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414223/ https://www.ncbi.nlm.nih.gov/pubmed/22888236 http://dx.doi.org/10.2147/IJN.S33101

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