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Human Papillomavirus Vaccination in Tanzanian Schoolgirls: Cluster-Randomized Trial Comparing 2 Vaccine-Delivery Strategies

Background.We compared vaccine coverage achieved by 2 different delivery strategies for the quadrivalent human papillomavirus (HPV) vaccine in Tanzanian schoolgirls. Methods.In a cluster-randomized trial of HPV vaccination conducted in Tanzania, 134 primary schools were randomly assigned to class-ba...

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Autores principales: Watson-Jones, Deborah, Baisley, Kathy, Ponsiano, Riziki, Lemme, Francesca, Remes, Pieter, Ross, David, Kapiga, Saidi, Mayaud, Philippe, de Sanjosé, Silvia, Wight, Daniel, Changalucha, John, Hayes, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414230/
https://www.ncbi.nlm.nih.gov/pubmed/22711908
http://dx.doi.org/10.1093/infdis/jis407
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author Watson-Jones, Deborah
Baisley, Kathy
Ponsiano, Riziki
Lemme, Francesca
Remes, Pieter
Ross, David
Kapiga, Saidi
Mayaud, Philippe
de Sanjosé, Silvia
Wight, Daniel
Changalucha, John
Hayes, Richard
author_facet Watson-Jones, Deborah
Baisley, Kathy
Ponsiano, Riziki
Lemme, Francesca
Remes, Pieter
Ross, David
Kapiga, Saidi
Mayaud, Philippe
de Sanjosé, Silvia
Wight, Daniel
Changalucha, John
Hayes, Richard
author_sort Watson-Jones, Deborah
collection PubMed
description Background.We compared vaccine coverage achieved by 2 different delivery strategies for the quadrivalent human papillomavirus (HPV) vaccine in Tanzanian schoolgirls. Methods.In a cluster-randomized trial of HPV vaccination conducted in Tanzania, 134 primary schools were randomly assigned to class-based (girls enrolled in primary school grade [class] 6) or age-based (girls born in 1998; 67 schools per arm) vaccine delivery. The primary outcome was coverage by dose. Results.There were 3352 and 2180 eligible girls in schools randomized to class-based and age-based delivery, respectively. HPV vaccine coverage was 84.7% for dose 1, 81.4% for dose 2, and 76.1% for dose 3. For each dose, coverage was higher in class-based schools than in age-based schools (dose 1: 86.4% vs 82.0% [P = .30]; dose 2: 83.8% vs 77.8% [P = .05]; and dose 3: 78.7% vs 72.1% [P = .04]). Vaccine-related adverse events were rare. Reasons for not vaccinating included absenteeism (6.3%) and parent refusal (6.7%). School absenteeism rates prior to vaccination ranged from 8.1% to 23.5%. Conclusions.HPV vaccine can be delivered with high coverage in schools in sub-Saharan Africa. Compared with age-based vaccination, class-based vaccination located more eligible pupils and achieved higher coverage. HPV vaccination did not increase absenteeism rates in selected schools. Innovative strategies will be needed to reach out-of-school girls. Clinical Trials Registration. NCT01173900.
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spelling pubmed-34142302012-08-08 Human Papillomavirus Vaccination in Tanzanian Schoolgirls: Cluster-Randomized Trial Comparing 2 Vaccine-Delivery Strategies Watson-Jones, Deborah Baisley, Kathy Ponsiano, Riziki Lemme, Francesca Remes, Pieter Ross, David Kapiga, Saidi Mayaud, Philippe de Sanjosé, Silvia Wight, Daniel Changalucha, John Hayes, Richard J Infect Dis Major Articles and Brief Reports Background.We compared vaccine coverage achieved by 2 different delivery strategies for the quadrivalent human papillomavirus (HPV) vaccine in Tanzanian schoolgirls. Methods.In a cluster-randomized trial of HPV vaccination conducted in Tanzania, 134 primary schools were randomly assigned to class-based (girls enrolled in primary school grade [class] 6) or age-based (girls born in 1998; 67 schools per arm) vaccine delivery. The primary outcome was coverage by dose. Results.There were 3352 and 2180 eligible girls in schools randomized to class-based and age-based delivery, respectively. HPV vaccine coverage was 84.7% for dose 1, 81.4% for dose 2, and 76.1% for dose 3. For each dose, coverage was higher in class-based schools than in age-based schools (dose 1: 86.4% vs 82.0% [P = .30]; dose 2: 83.8% vs 77.8% [P = .05]; and dose 3: 78.7% vs 72.1% [P = .04]). Vaccine-related adverse events were rare. Reasons for not vaccinating included absenteeism (6.3%) and parent refusal (6.7%). School absenteeism rates prior to vaccination ranged from 8.1% to 23.5%. Conclusions.HPV vaccine can be delivered with high coverage in schools in sub-Saharan Africa. Compared with age-based vaccination, class-based vaccination located more eligible pupils and achieved higher coverage. HPV vaccination did not increase absenteeism rates in selected schools. Innovative strategies will be needed to reach out-of-school girls. Clinical Trials Registration. NCT01173900. Oxford University Press 2012-09-01 2012-06-18 /pmc/articles/PMC3414230/ /pubmed/22711908 http://dx.doi.org/10.1093/infdis/jis407 Text en © The Author 2012. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please email: journals.permissions@oup.com. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Major Articles and Brief Reports
Watson-Jones, Deborah
Baisley, Kathy
Ponsiano, Riziki
Lemme, Francesca
Remes, Pieter
Ross, David
Kapiga, Saidi
Mayaud, Philippe
de Sanjosé, Silvia
Wight, Daniel
Changalucha, John
Hayes, Richard
Human Papillomavirus Vaccination in Tanzanian Schoolgirls: Cluster-Randomized Trial Comparing 2 Vaccine-Delivery Strategies
title Human Papillomavirus Vaccination in Tanzanian Schoolgirls: Cluster-Randomized Trial Comparing 2 Vaccine-Delivery Strategies
title_full Human Papillomavirus Vaccination in Tanzanian Schoolgirls: Cluster-Randomized Trial Comparing 2 Vaccine-Delivery Strategies
title_fullStr Human Papillomavirus Vaccination in Tanzanian Schoolgirls: Cluster-Randomized Trial Comparing 2 Vaccine-Delivery Strategies
title_full_unstemmed Human Papillomavirus Vaccination in Tanzanian Schoolgirls: Cluster-Randomized Trial Comparing 2 Vaccine-Delivery Strategies
title_short Human Papillomavirus Vaccination in Tanzanian Schoolgirls: Cluster-Randomized Trial Comparing 2 Vaccine-Delivery Strategies
title_sort human papillomavirus vaccination in tanzanian schoolgirls: cluster-randomized trial comparing 2 vaccine-delivery strategies
topic Major Articles and Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414230/
https://www.ncbi.nlm.nih.gov/pubmed/22711908
http://dx.doi.org/10.1093/infdis/jis407
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