2,2-Diethyl 3,4-dimethyl 5-(4-cyano­phen­yl)pyrrolidine-2,2,3,4-tetra­carboxyl­ate

The title compound, C(21)H(24)N(2)O(8), was synthesized by a 1,3-dipolar cyclo­addition reaction of dimethyl fumarate, diethyl 2-amino­malonate and 4-cyano­benzaldehyde. Both methyl ester groups display a trans configuration and the pyrrolidine ring possesses an envelope conformation, with the C ato...

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Detalles Bibliográficos
Autor principal: He, Long
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2012
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414296/
https://www.ncbi.nlm.nih.gov/pubmed/22904829
http://dx.doi.org/10.1107/S1600536812029625
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author He, Long
author_facet He, Long
author_sort He, Long
collection PubMed
description The title compound, C(21)H(24)N(2)O(8), was synthesized by a 1,3-dipolar cyclo­addition reaction of dimethyl fumarate, diethyl 2-amino­malonate and 4-cyano­benzaldehyde. Both methyl ester groups display a trans configuration and the pyrrolidine ring possesses an envelope conformation, with the C atom in the 3-position as the flap. In the crystal, N—H⋯N hydrogen bonds and weak C—H⋯O inter­actions occur.
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spelling pubmed-34142962012-08-17 2,2-Diethyl 3,4-dimethyl 5-(4-cyano­phen­yl)pyrrolidine-2,2,3,4-tetra­carboxyl­ate He, Long Acta Crystallogr Sect E Struct Rep Online Organic Papers The title compound, C(21)H(24)N(2)O(8), was synthesized by a 1,3-dipolar cyclo­addition reaction of dimethyl fumarate, diethyl 2-amino­malonate and 4-cyano­benzaldehyde. Both methyl ester groups display a trans configuration and the pyrrolidine ring possesses an envelope conformation, with the C atom in the 3-position as the flap. In the crystal, N—H⋯N hydrogen bonds and weak C—H⋯O inter­actions occur. International Union of Crystallography 2012-07-07 /pmc/articles/PMC3414296/ /pubmed/22904829 http://dx.doi.org/10.1107/S1600536812029625 Text en © Long He 2012 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
He, Long
2,2-Diethyl 3,4-dimethyl 5-(4-cyano­phen­yl)pyrrolidine-2,2,3,4-tetra­carboxyl­ate
title 2,2-Diethyl 3,4-dimethyl 5-(4-cyano­phen­yl)pyrrolidine-2,2,3,4-tetra­carboxyl­ate
title_full 2,2-Diethyl 3,4-dimethyl 5-(4-cyano­phen­yl)pyrrolidine-2,2,3,4-tetra­carboxyl­ate
title_fullStr 2,2-Diethyl 3,4-dimethyl 5-(4-cyano­phen­yl)pyrrolidine-2,2,3,4-tetra­carboxyl­ate
title_full_unstemmed 2,2-Diethyl 3,4-dimethyl 5-(4-cyano­phen­yl)pyrrolidine-2,2,3,4-tetra­carboxyl­ate
title_short 2,2-Diethyl 3,4-dimethyl 5-(4-cyano­phen­yl)pyrrolidine-2,2,3,4-tetra­carboxyl­ate
title_sort 2,2-diethyl 3,4-dimethyl 5-(4-cyano­phen­yl)pyrrolidine-2,2,3,4-tetra­carboxyl­ate
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414296/
https://www.ncbi.nlm.nih.gov/pubmed/22904829
http://dx.doi.org/10.1107/S1600536812029625
work_keys_str_mv AT helong 22diethyl34dimethyl54cyanophenylpyrrolidine2234tetracarboxylate

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