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2,2-Diethyl 3,4-dimethyl 5-(4-cyanophenyl)pyrrolidine-2,2,3,4-tetracarboxylate
The title compound, C(21)H(24)N(2)O(8), was synthesized by a 1,3-dipolar cycloaddition reaction of dimethyl fumarate, diethyl 2-aminomalonate and 4-cyanobenzaldehyde. Both methyl ester groups display a trans configuration and the pyrrolidine ring possesses an envelope conformation, with the C ato...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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International Union of Crystallography
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414296/ https://www.ncbi.nlm.nih.gov/pubmed/22904829 http://dx.doi.org/10.1107/S1600536812029625 |
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author | He, Long |
author_facet | He, Long |
author_sort | He, Long |
collection | PubMed |
description | The title compound, C(21)H(24)N(2)O(8), was synthesized by a 1,3-dipolar cycloaddition reaction of dimethyl fumarate, diethyl 2-aminomalonate and 4-cyanobenzaldehyde. Both methyl ester groups display a trans configuration and the pyrrolidine ring possesses an envelope conformation, with the C atom in the 3-position as the flap. In the crystal, N—H⋯N hydrogen bonds and weak C—H⋯O interactions occur. |
format | Online Article Text |
id | pubmed-3414296 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | International Union of Crystallography |
record_format | MEDLINE/PubMed |
spelling | pubmed-34142962012-08-17 2,2-Diethyl 3,4-dimethyl 5-(4-cyanophenyl)pyrrolidine-2,2,3,4-tetracarboxylate He, Long Acta Crystallogr Sect E Struct Rep Online Organic Papers The title compound, C(21)H(24)N(2)O(8), was synthesized by a 1,3-dipolar cycloaddition reaction of dimethyl fumarate, diethyl 2-aminomalonate and 4-cyanobenzaldehyde. Both methyl ester groups display a trans configuration and the pyrrolidine ring possesses an envelope conformation, with the C atom in the 3-position as the flap. In the crystal, N—H⋯N hydrogen bonds and weak C—H⋯O interactions occur. International Union of Crystallography 2012-07-07 /pmc/articles/PMC3414296/ /pubmed/22904829 http://dx.doi.org/10.1107/S1600536812029625 Text en © Long He 2012 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited. |
spellingShingle | Organic Papers He, Long 2,2-Diethyl 3,4-dimethyl 5-(4-cyanophenyl)pyrrolidine-2,2,3,4-tetracarboxylate |
title | 2,2-Diethyl 3,4-dimethyl 5-(4-cyanophenyl)pyrrolidine-2,2,3,4-tetracarboxylate |
title_full | 2,2-Diethyl 3,4-dimethyl 5-(4-cyanophenyl)pyrrolidine-2,2,3,4-tetracarboxylate |
title_fullStr | 2,2-Diethyl 3,4-dimethyl 5-(4-cyanophenyl)pyrrolidine-2,2,3,4-tetracarboxylate |
title_full_unstemmed | 2,2-Diethyl 3,4-dimethyl 5-(4-cyanophenyl)pyrrolidine-2,2,3,4-tetracarboxylate |
title_short | 2,2-Diethyl 3,4-dimethyl 5-(4-cyanophenyl)pyrrolidine-2,2,3,4-tetracarboxylate |
title_sort | 2,2-diethyl 3,4-dimethyl 5-(4-cyanophenyl)pyrrolidine-2,2,3,4-tetracarboxylate |
topic | Organic Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414296/ https://www.ncbi.nlm.nih.gov/pubmed/22904829 http://dx.doi.org/10.1107/S1600536812029625 |
work_keys_str_mv | AT helong 22diethyl34dimethyl54cyanophenylpyrrolidine2234tetracarboxylate |