Increased Generation of TRAP Expressing Multinucleated Giant Cells in Patients with Granulomatosis with Polyangiitis

BACKGROUND: Tissue-infiltrating multinucleated giant cells (MNGs) within geographic necrosis are pathologic hallmarks of granulomatosis with polyangiitis (GPA). However, the origin, phenotype, and function of these cells in GPA remain undefined. METHODOLOGY/PRINCIPAL FINDINGS: MNG phenotype in GPA l...

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Detalles Bibliográficos
Autores principales: Park, Jin Kyun, Askin, Frederic, Giles, Jon T., Halushka, Marc K., Rosen, Antony, Levine, Stuart M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414441/
https://www.ncbi.nlm.nih.gov/pubmed/22905158
http://dx.doi.org/10.1371/journal.pone.0042659

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