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p53 Dimers Associate with a Head-to-Tail Response Element to Repress Cyclin B Transcription

DNA damage induced by the topoisomerase I inhibitor SN38 activates cell cycle checkpoints which promote cell cycle arrest. This arrest can be abrogated in p53-defective cells by the Chk1 inhibitor 7-hydroxystaurosporine (UCN-01). Previously, we compared p53 wild-type MCF10A cells with derivatives wh...

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Detalles Bibliográficos
Autores principales:	Lipski, Robert, Lippincott, Daniel J., Durden, Brittany C., Kaplan, Anne R., Keiser, Hilary E., Park, Jung-Ho, Levesque, Aime A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414442/ https://www.ncbi.nlm.nih.gov/pubmed/22905155 http://dx.doi.org/10.1371/journal.pone.0042615

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