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Porous Surface Modified Bioactive Bone Cement for Enhanced Bone Bonding
BACKGROUND: Polymethylmethacrylate bone cement cannot provide an adhesive chemical bonding to form a stable cement-bone interface. Bioactive bone cements show bone bonding ability, but their clinical application is limited because bone resorption is observed after implantation. Porous polymethylmeth...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414445/ https://www.ncbi.nlm.nih.gov/pubmed/22905143 http://dx.doi.org/10.1371/journal.pone.0042525 |
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author | He, Qiang Chen, Huiling Huang, Li Dong, Jingjing Guo, Dagang Mao, Mengmeng Kong, Liang Li, Yang Wu, Zixiang Lei, Wei |
author_facet | He, Qiang Chen, Huiling Huang, Li Dong, Jingjing Guo, Dagang Mao, Mengmeng Kong, Liang Li, Yang Wu, Zixiang Lei, Wei |
author_sort | He, Qiang |
collection | PubMed |
description | BACKGROUND: Polymethylmethacrylate bone cement cannot provide an adhesive chemical bonding to form a stable cement-bone interface. Bioactive bone cements show bone bonding ability, but their clinical application is limited because bone resorption is observed after implantation. Porous polymethylmethacrylate can be achieved with the addition of carboxymethylcellulose, alginate and gelatin microparticles to promote bone ingrowth, but the mechanical properties are too low to be used in orthopedic applications. Bone ingrowth into cement could decrease the possibility of bone resorption and promote the formation of a stable interface. However, scarce literature is reported on bioactive bone cements that allow bone ingrowth. In this paper, we reported a porous surface modified bioactive bone cement with desired mechanical properties, which could allow for bone ingrowth. MATERIALS AND METHODS: The porous surface modified bioactive bone cement was evaluated to determine its handling characteristics, mechanical properties and behavior in a simulated body fluid. The in vitro cellular responses of the samples were also investigated in terms of cell attachment, proliferation, and osteoblastic differentiation. Furthermore, bone ingrowth was examined in a rabbit femoral condyle defect model by using micro-CT imaging and histological analysis. The strength of the implant–bone interface was also investigated by push-out tests. RESULTS: The modified bone cement with a low content of bioactive fillers resulted in proper handling characteristics and adequate mechanical properties, but slightly affected its bioactivity. Moreover, the degree of attachment, proliferation and osteogenic differentiation of preosteoblast cells was also increased. The results of the push-out test revealed that higher interfacial bonding strength was achieved with the modified bone cement because of the formation of the apatite layer and the osseointegration after implantation in the bony defect. CONCLUSIONS: Our findings suggested a new bioactive bone cement for prosthetic fixation in total joint replacement. |
format | Online Article Text |
id | pubmed-3414445 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-34144452012-08-19 Porous Surface Modified Bioactive Bone Cement for Enhanced Bone Bonding He, Qiang Chen, Huiling Huang, Li Dong, Jingjing Guo, Dagang Mao, Mengmeng Kong, Liang Li, Yang Wu, Zixiang Lei, Wei PLoS One Research Article BACKGROUND: Polymethylmethacrylate bone cement cannot provide an adhesive chemical bonding to form a stable cement-bone interface. Bioactive bone cements show bone bonding ability, but their clinical application is limited because bone resorption is observed after implantation. Porous polymethylmethacrylate can be achieved with the addition of carboxymethylcellulose, alginate and gelatin microparticles to promote bone ingrowth, but the mechanical properties are too low to be used in orthopedic applications. Bone ingrowth into cement could decrease the possibility of bone resorption and promote the formation of a stable interface. However, scarce literature is reported on bioactive bone cements that allow bone ingrowth. In this paper, we reported a porous surface modified bioactive bone cement with desired mechanical properties, which could allow for bone ingrowth. MATERIALS AND METHODS: The porous surface modified bioactive bone cement was evaluated to determine its handling characteristics, mechanical properties and behavior in a simulated body fluid. The in vitro cellular responses of the samples were also investigated in terms of cell attachment, proliferation, and osteoblastic differentiation. Furthermore, bone ingrowth was examined in a rabbit femoral condyle defect model by using micro-CT imaging and histological analysis. The strength of the implant–bone interface was also investigated by push-out tests. RESULTS: The modified bone cement with a low content of bioactive fillers resulted in proper handling characteristics and adequate mechanical properties, but slightly affected its bioactivity. Moreover, the degree of attachment, proliferation and osteogenic differentiation of preosteoblast cells was also increased. The results of the push-out test revealed that higher interfacial bonding strength was achieved with the modified bone cement because of the formation of the apatite layer and the osseointegration after implantation in the bony defect. CONCLUSIONS: Our findings suggested a new bioactive bone cement for prosthetic fixation in total joint replacement. Public Library of Science 2012-08-08 /pmc/articles/PMC3414445/ /pubmed/22905143 http://dx.doi.org/10.1371/journal.pone.0042525 Text en © 2012 He et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article He, Qiang Chen, Huiling Huang, Li Dong, Jingjing Guo, Dagang Mao, Mengmeng Kong, Liang Li, Yang Wu, Zixiang Lei, Wei Porous Surface Modified Bioactive Bone Cement for Enhanced Bone Bonding |
title | Porous Surface Modified Bioactive Bone Cement for Enhanced Bone Bonding |
title_full | Porous Surface Modified Bioactive Bone Cement for Enhanced Bone Bonding |
title_fullStr | Porous Surface Modified Bioactive Bone Cement for Enhanced Bone Bonding |
title_full_unstemmed | Porous Surface Modified Bioactive Bone Cement for Enhanced Bone Bonding |
title_short | Porous Surface Modified Bioactive Bone Cement for Enhanced Bone Bonding |
title_sort | porous surface modified bioactive bone cement for enhanced bone bonding |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414445/ https://www.ncbi.nlm.nih.gov/pubmed/22905143 http://dx.doi.org/10.1371/journal.pone.0042525 |
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