Biophysical Characterization of Met-G-CSF: Effects of Different Site-Specific Mono-Pegylations on Protein Stability and Aggregation

The limited stability of proteins in vitro and in vivo reduces their conversion into effective biopharmaceuticals. To overcome this problem several strategies can be exploited, as the conjugation of the protein of interest with polyethylene glycol, in most cases, improves its stability and pharmacok...

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Detalles Bibliográficos
Autores principales: Natalello, Antonino, Ami, Diletta, Collini, Maddalena, D’Alfonso, Laura, Chirico, Giuseppe, Tonon, Giancarlo, Scaramuzza, Silvia, Schrepfer, Rodolfo, Doglia, Silvia Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414461/
https://www.ncbi.nlm.nih.gov/pubmed/22905140
http://dx.doi.org/10.1371/journal.pone.0042511

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414461/
https://www.ncbi.nlm.nih.gov/pubmed/22905140
http://dx.doi.org/10.1371/journal.pone.0042511

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