Ucp2 Induced by Natural Birth Regulates Neuronal Differentiation of the Hippocampus and Related Adult Behavior

Mitochondrial uncoupling protein 2 (UCP2) is induced by cellular stress and is involved in regulation of fuel utilization, mitochondrial bioenergetics, cell proliferation, neuroprotection and synaptogenesis in the adult brain. Here we show that natural birth in mice triggers UCP2 expression in hippo...

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Detalles Bibliográficos
Autores principales: Simon-Areces, Julia, Dietrich, Marcelo O., Hermes, Gretchen, Garcia-Segura, Luis Miguel, Arevalo, Maria-Angeles, Horvath, Tamas L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414493/
https://www.ncbi.nlm.nih.gov/pubmed/22905184
http://dx.doi.org/10.1371/journal.pone.0042911
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author Simon-Areces, Julia
Dietrich, Marcelo O.
Hermes, Gretchen
Garcia-Segura, Luis Miguel
Arevalo, Maria-Angeles
Horvath, Tamas L.
author_facet Simon-Areces, Julia
Dietrich, Marcelo O.
Hermes, Gretchen
Garcia-Segura, Luis Miguel
Arevalo, Maria-Angeles
Horvath, Tamas L.
author_sort Simon-Areces, Julia
collection PubMed
description Mitochondrial uncoupling protein 2 (UCP2) is induced by cellular stress and is involved in regulation of fuel utilization, mitochondrial bioenergetics, cell proliferation, neuroprotection and synaptogenesis in the adult brain. Here we show that natural birth in mice triggers UCP2 expression in hippocampal neurons. Chemical inhibition or genetic ablation of UCP2 lead to diminished neuronal number and size, dendritic growth and synaptogenezis in vitro and impaired complex behaviors in the adult. These data reveal a critical role for Ucp2 expression in the development of hippocampal neurons and circuits and hippocampus-related adult behaviors.
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spelling pubmed-34144932012-08-19 Ucp2 Induced by Natural Birth Regulates Neuronal Differentiation of the Hippocampus and Related Adult Behavior Simon-Areces, Julia Dietrich, Marcelo O. Hermes, Gretchen Garcia-Segura, Luis Miguel Arevalo, Maria-Angeles Horvath, Tamas L. PLoS One Research Article Mitochondrial uncoupling protein 2 (UCP2) is induced by cellular stress and is involved in regulation of fuel utilization, mitochondrial bioenergetics, cell proliferation, neuroprotection and synaptogenesis in the adult brain. Here we show that natural birth in mice triggers UCP2 expression in hippocampal neurons. Chemical inhibition or genetic ablation of UCP2 lead to diminished neuronal number and size, dendritic growth and synaptogenezis in vitro and impaired complex behaviors in the adult. These data reveal a critical role for Ucp2 expression in the development of hippocampal neurons and circuits and hippocampus-related adult behaviors. Public Library of Science 2012-08-08 /pmc/articles/PMC3414493/ /pubmed/22905184 http://dx.doi.org/10.1371/journal.pone.0042911 Text en © 2012 Simon-Areces et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Simon-Areces, Julia
Dietrich, Marcelo O.
Hermes, Gretchen
Garcia-Segura, Luis Miguel
Arevalo, Maria-Angeles
Horvath, Tamas L.
Ucp2 Induced by Natural Birth Regulates Neuronal Differentiation of the Hippocampus and Related Adult Behavior
title Ucp2 Induced by Natural Birth Regulates Neuronal Differentiation of the Hippocampus and Related Adult Behavior
title_full Ucp2 Induced by Natural Birth Regulates Neuronal Differentiation of the Hippocampus and Related Adult Behavior
title_fullStr Ucp2 Induced by Natural Birth Regulates Neuronal Differentiation of the Hippocampus and Related Adult Behavior
title_full_unstemmed Ucp2 Induced by Natural Birth Regulates Neuronal Differentiation of the Hippocampus and Related Adult Behavior
title_short Ucp2 Induced by Natural Birth Regulates Neuronal Differentiation of the Hippocampus and Related Adult Behavior
title_sort ucp2 induced by natural birth regulates neuronal differentiation of the hippocampus and related adult behavior
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414493/
https://www.ncbi.nlm.nih.gov/pubmed/22905184
http://dx.doi.org/10.1371/journal.pone.0042911
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